INT178754

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 10.10
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
embryos 4
neuronal 4
MCF-7 2
cleavage 2
HT-29 2
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 87 100.00 Very High Very High Very High
metalloproteinase 87 100.00 Very High Very High Very High
Migraine 44 100.00 Very High Very High Very High
Calcitonin gene-related peptide 66 99.96 Very High Very High Very High
Enkephalin 80 99.36 Very High Very High Very High
Central nervous system 7 99.08 Very High Very High Very High
Pain 222 98.36 Very High Very High Very High
agonist 264 96.44 Very High Very High Very High
Chronic low back pain 18 95.76 Very High Very High Very High
Opioid 135 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 179 100.00 Very High Very High Very High
Disease 125 100.00 Very High Very High Very High
Headache 53 100.00 Very High Very High Very High
Cancer 207 99.96 Very High Very High Very High
Giant Cell Tumors 30 99.16 Very High Very High Very High
Anxiety Disorder 47 98.74 Very High Very High Very High
Colon Cancer 76 98.40 Very High Very High Very High
Pain 221 98.36 Very High Very High Very High
Nociception 51 97.40 Very High Very High Very High
Sprains And Strains 16 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient had an uneventful recovery.Fig3Resected tumor mass extending up to the joint
Positive_regulation (uneventful) of Localization (3Resected) of Fig in joint associated with cancer
1) Confidence 0.43 Published 2009 Journal J Orthop Traumatol Section Body Doc Link PMC2784057 Disease Relevance 1.09 Pain Relevance 0.09
However, differences in testing equipment, testing position and protocol create difficulties for within-sex comparison of grip strength across Denmark, Japan and the US and, thus, the results should be interpreted cautiously (Fig. 2).Fig. 2Grip strength

Physical disabilities

Positive_regulation (cautiously) of Localization (interpreted) of Fig
2) Confidence 0.40 Published 2010 Journal Eur J Epidemiol Section Body Doc Link PMC2903692 Disease Relevance 0 Pain Relevance 0
Fig1Locations (by level 3 administrative unit) where male circumcision (MC) acceptability studies were conducted
Positive_regulation (conducted) of Localization (1Locations) of Fig
3) Confidence 0.39 Published 2006 Journal AIDS Behav Section Body Doc Link PMC1847541 Disease Relevance 0.29 Pain Relevance 0
In six animals lesions after surgery in both eyeballs were comparable or they were not noticed at all.Fig. 1Clinical observations: a Duration of clinical symptoms during 30-day observation; group C control group (eyeballs without implant), group I study group (eyeballs with inserted implant); b Maximum of intensity of clinical symptoms and the course of wound healing after 30-day observation; a statistical difference SD between groups P ? 
Neg (not) Positive_regulation (at) of Spec (observations) Localization (observations) of Fig associated with wound healing
4) Confidence 0.33 Published 2010 Journal J Mater Sci Mater Med Section Body Doc Link PMC2962782 Disease Relevance 0.65 Pain Relevance 0
The data demonstrate that lengthening the lag-alone segment increased the frequency with which saccades were lag-directed (Fig. 6B; subject C: P?
Positive_regulation (increased) of Localization (directed) of Fig
5) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2571984 Disease Relevance 0 Pain Relevance 0
In contrast, radiation up to 10 Gy was not sufficient to induce significant PARP-cleavage (Fig. 9C and data not shown).
Positive_regulation (induce) of Localization (cleavage) of Fig in cleavage
6) Confidence 0.28 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1475859 Disease Relevance 0.99 Pain Relevance 0
Fig. 4), as sometimes prolongations of neuronal responses have been reported during BIC-application (e.g.
Positive_regulation (during) of Localization (reported) of Fig in neuronal
7) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253823 Disease Relevance 0 Pain Relevance 0
Fig. 4), as sometimes prolongations of neuronal responses have been reported during BIC-application (e.g.
Positive_regulation (during) of Localization (application) of Fig in neuronal
8) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253823 Disease Relevance 0 Pain Relevance 0
M), which is often used to induce Ca2+ release from endoplasmic reticulum, increased intracellular Ca2+ in MCF-7 cells (Fig. 2C, n = 20).
Positive_regulation (induce) of Localization (release) of Fig in MCF-7
9) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.08 Pain Relevance 0.03
Other distributions between pain intensity or pain related fears (TSK or FABQ) and performance variables were similar, but they are not presented.Fig. 1Plot of maximum lifting performance and scores on the Tampa Scale for Kinesiophobia (TSK) in 79 patients with chronic low back pain
Neg (not) Positive_regulation (not) of Localization (1Plot) of Fig in Tampa associated with low back pain, chronic low back pain, pain and anxiety disorder
10) Confidence 0.21 Published 2007 Journal J Occup Rehabil Section Body Doc Link PMC1915618 Disease Relevance 1.21 Pain Relevance 0.83
-endorphin release after selective TLR activation (Fig. 2 and Fig.
Positive_regulation (activation) of Localization (release) of Fig
11) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.40 Pain Relevance 0.66
-endorphin release after selective TLR activation (Fig. 2 and Fig.
Positive_regulation (activation) of Localization (release) of Fig
12) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.40 Pain Relevance 0.66
S340A was fully desensitized following secondary U46619-stimulation (Fig. 5M–O) while that of TP?
Positive_regulation (stimulation) of Localization (desensitized) of Fig
13) Confidence 0.12 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
T337,340A with U46619 yielded efficient increases in [Ca2+]i mobilization (Fig. 6C and E, respectively) and IP3 generation (data not shown), in each case the level of agonist-induced desensitization was not significantly different to that of their respective single mutants TP?
Positive_regulation (increases) of Localization (mobilization) of Fig associated with agonist
14) Confidence 0.12 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
This shows that Gi-protein dependent signals elicit CRC cell proliferation, as corroborated by the ability of PTX to block PGE2 or LPA induced proliferation (Fig. 4B and data not shown).
Positive_regulation (induced) of Localization (proliferation) of Fig associated with colon cancer
15) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.16 Pain Relevance 0.09
Fig. 1In migraine attacks, sensory nerves, which innervate the cerebral blood vessels, are activated to antidromically release calcitonin gene-related peptide.
Positive_regulation (activated) of Localization (release) of Fig in sensory nerves associated with migraine and calcitonin gene-related peptide
16) Confidence 0.10 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.80 Pain Relevance 0.88
At high enough concentrations, ACh auto-antagonized 100% its own induced secretion, Fig 9A.
Positive_regulation (induced) of Localization (secretion) of Fig
17) Confidence 0.10 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0.32
mol/l) led to significantly increased (2.4-fold) RBP4 release into the media (450 ng/ml [177.2–809.9], P = 0.005) (Fig. 5A).
Positive_regulation (increased) of Localization (release) of Fig
18) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.31 Pain Relevance 0
g/ml), does not affect TET's stimulation of AA release from HT-29 cells, such treatment does inhibit THAP's stimulation of AA release from the HT-29 cells (Fig. 3, Table 1).
Positive_regulation (stimulation) of Localization (release) of Fig in HT-29
19) Confidence 0.09 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1180457 Disease Relevance 0.13 Pain Relevance 0
Surprisingly, despite evidence of unregulated activation, Rab7 disease mutants have normal subcellular localization and associate normally with LAMP2 (Fig. 5B) and LysoTracker Red (data not shown).
Positive_regulation (activation) of Localization (localization) of Fig associated with disease
20) Confidence 0.08 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.56 Pain Relevance 0

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