INT178763

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 6.30
Pain Relevance 5.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HHIP) plasma membrane (HHIP) carbohydrate metabolic process (HHIP)
cytoplasm (HHIP)
Anatomy Link Frequency
plasma 4
hip 4
tail 3
upper 3
spine 2
HHIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 21 100.00 Very High Very High Very High
agonist 2968 99.82 Very High Very High Very High
imagery 196 99.54 Very High Very High Very High
Lasting pain 4 98.92 Very High Very High Very High
depression 5 97.92 Very High Very High Very High
backache 2 89.84 High High
Restless leg syndrome 4 87.52 High High
Dopamine 28 65.12 Quite High
Inflammation 6 40.80 Quite Low
dopamine receptor 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hip Fractures 31 100.00 Very High Very High Very High
Pain 22 100.00 Very High Very High Very High
Arthralgia 4 100.00 Very High Very High Very High
Cleidocranial Dysplasia 18 99.96 Very High Very High Very High
Osteoporosis 249 99.74 Very High Very High Very High
Atherosclerosis 36 99.28 Very High Very High Very High
Ovarian Cancer 2 98.68 Very High Very High Very High
Depression 5 97.92 Very High Very High Very High
Death 3 96.80 Very High Very High Very High
Frailty 103 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteoporosis can also be diagnosed by bone densitometry of the hip, lumbar vertebrae, or the radius (distal one-third) as per World Health Organization (WHO) guidelines.6 A T-score of ?
hip Binding (diagnosed) of in radius associated with osteoporosis
1) Confidence 0.08 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998805 Disease Relevance 1.42 Pain Relevance 0.16
Our multiple regression analyses could not reveal significant independent associations of any of the considered lipid and lipoprotein components with hip or spine BMD.
hip Binding (associations) of in spine
2) Confidence 0.06 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.54 Pain Relevance 0
Moreover, studies show that the rate of demineralization at the hip is significantly associated with the rate of atherogenesis [5] and even future risk of cardiovascular events [37].
hip Binding (associated) of in hip associated with atherosclerosis
3) Confidence 0.06 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.85 Pain Relevance 0.09
Fractures of the spine and hip are associated with an increased risk of chronic pain, deformity, depression, disability, and death.
hip Binding (associated) of in hip associated with depression, lasting pain and death
4) Confidence 0.05 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC493281 Disease Relevance 0.89 Pain Relevance 0.15
One patient had hip joint pain after the operation and another patient had thigh pain, but these symptoms were not associated with loosening and they did not limit the patients' activity.
hip Neg (not) Binding (associated) of in hip joint associated with pain and arthralgia
5) Confidence 0.05 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2915393 Disease Relevance 0.43 Pain Relevance 0.20
One patient had hip joint pain after the operation and another patient had thigh pain, but these symptoms were not associated with loosening and they did not limit the patients' activity.
hip Neg (not) Binding (limit) of in hip joint associated with pain and arthralgia
6) Confidence 0.05 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2915393 Disease Relevance 0.43 Pain Relevance 0.20
This is important for an insufficient acetabulum in a patient with hip dysplasia.
hip Binding (patient) of in hip associated with cleidocranial dysplasia
7) Confidence 0.05 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2915393 Disease Relevance 0.27 Pain Relevance 0
Taken together, these data clearly suggest that GTP-binding or hydrolysis may not be a limiting factor for Rab5:hIP complex formation but from immunolocalizations involving Rab5aS34N, GTP-loading is necessary to drive endosome formation and hIP sorting to such endosomes.
hIP Binding (formation) of
8) Confidence 0.04 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.22
Similarly, immuno-detection with anti-GFP showed that the hIP and Rab5a interaction was enhanced in response to agonist (data not shown).
hIP Binding (interaction) of associated with agonist
9) Confidence 0.04 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.25
Hip fractures are associated with the highest degree of morbidity and mortality of all fractures with an associated 1-year mortality up to 15–25%.
Hip Binding (associated) of in Hip associated with hip fractures
10) Confidence 0.03 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2974929 Disease Relevance 0.58 Pain Relevance 0
Whilst incubation of the cells over-expressing Rab5aS34N with cicaprost for 2 h led to internalization of the hIP, consistent with the ELISA-based internalization studies the extent of relocalization of the hIP away from the plasma membrane was significantly impaired and the pattern of intracellular staining was more diffuse, lacking the distinct vesicular pattern observed in the HEK.hIP cells expressing the wild type Rab5a (Fig. 2B, Anti-HA).
hIP Binding (internalization) of in plasma
11) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.12
Hence, herein, we sought to clarify the requirement for the C-tail in hIP internalization in HEK 293 cells.
hIP Binding (internalization) of in tail
12) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.06
Likewise, the constitutively active, GTPase defective Rab5aQ79L co-immunoprecipitated with the hIP to levels that were somewhat higher than that of the wild type Rab5a even in the absence of agonist (Fig. 5, upper panel).
hIP Binding (immunoprecipitated) of in upper associated with agonist
13) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.27
Furthermore, agonist stimulation caused an increased association between the hIP and Rab5aS34N (Fig. 5; upper panel).
hIP Binding (association) of in upper associated with agonist
14) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.26
The extent of association between the hIP and Rab5aS34N was similar to that of wild type Rab5a (Fig. 5; upper panel) as were the amount of hIP present in the immunoprecipitates and the levels of GFP-Rab5a and -Rab5aS34N over-expression in the HEK.hIP cells (Fig. 5, middle and lower panels, respectively).
hIP Binding (association) of in upper
15) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.25
To assess agonist-induced internalization of hIP or its mutated derivatives, the media was changed to serum-free MEM and thereafter, cells were treated with cicaprost (1 ?
hIP Binding (internalization) of associated with agonist
16) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.05
Taken together, these data clearly suggest that GTP-binding or hydrolysis may not be a limiting factor for Rab5:hIP complex formation but from immunolocalizations involving Rab5aS34N, GTP-loading is necessary to drive endosome formation and hIP sorting to such endosomes.
hIP Binding (formation) of
17) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.22
Moreover, the data herein suggests that while the C-tail domain of the hIP may not be essential for internalization per se, it does appear to be required to maintain the internalized receptor within the endocytic pool, preventing it from recycling back to the plasma membrane, such as occurs in the case of the hIP?
hIP Binding (domain) of in tail
18) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.04
It was notable that the time-dependent internalization of the hIP observed in the immunolocalization assays paralleled that observed in the ELISA-based assays, where maximum loss of cell surface expression is achieved by 1 h.
hIP Binding (internalization) of
19) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.10
In order to explain the role of Rab5 in the internalization of the hIP, we propose that on agonist stimulation, the hIP is initially recruited to CCVs at the plasma membrane.
hIP Binding (internalization) of in plasma associated with agonist
20) Confidence 0.03 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.16

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