INT178772

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.79
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
Notch 1
cleavage 1
plaques 1
App (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 55 98.64 Very High Very High Very High
cytokine 131 97.84 Very High Very High Very High
Spinal cord 12 93.88 High High
Hyperalgesia 2 93.28 High High
Central nervous system 114 89.04 High High
chemokine 31 86.72 High High
Inflammation 190 85.88 High High
long-term potentiation 10 80.32 Quite High
metalloproteinase 12 78.24 Quite High
agonist 119 77.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 176 100.00 Very High Very High Very High
Alzheimer's Dementia 153 100.00 Very High Very High Very High
Adhesions 14 99.92 Very High Very High Very High
Disease 912 99.72 Very High Very High Very High
Death 92 99.64 Very High Very High Very High
Amyloid Plaque 58 96.72 Very High Very High Very High
Frailty 27 94.16 High High
Hyperalgesia 2 93.28 High High
Apoptosis 151 92.00 High High
Sleep Disorders 2 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 induces the transcription of the APP gene, and the production of APP and A?
Transcription (transcription) of APP
1) Confidence 0.70 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.07 Pain Relevance 0
Like NICD (Notch intracellular domain), several recent studies have suggested that AICD has transactivation activity and can regulate transcription of multiple genes including APP, GSK-3?
Transcription (transcription) of APP in Notch
2) Confidence 0.69 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0 Pain Relevance 0.05
APP was found to colocalize with ?
Transcription (found) of APP
3) Confidence 0.69 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.23 Pain Relevance 0
In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK-3?
Transcription (transcription) of APP
4) Confidence 0.69 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.17 Pain Relevance 0
In the amyloid precursor protein (APP) transgenic model
Transcription (transgenic) of APP associated with targeted disruption and alzheimer's dementia
5) Confidence 0.63 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.82 Pain Relevance 0.67
In the amyloid precursor protein (APP) transgenic model
Transcription (transgenic) of amyloid precursor protein associated with targeted disruption and alzheimer's dementia
6) Confidence 0.63 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.83 Pain Relevance 0.68
The deletion of the TNF type 1 death receptor gene in APP23 transgenic mice, another transgenic mouse model of AD, inhibited A?
Transcription (transgenic mice) of APP23 associated with targeted disruption, disease and death
7) Confidence 0.62 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.54 Pain Relevance 0.30
In early studies, the existence of the shed ectodomain of APP was used to deduce the existence of the proteolytic activity designated ?
Transcription (ectodomain) of APP
8) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.04
This protocol avoids any confound that might arise because of altered APP transcription.
Transcription (transcription) of APP
9) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
In the human APP mRNAs, the G-rich region containing the putative G-quartet motif is found in all three splice variants (APP695, APP751, and APP770; 87 nucleotides upstream of the sequence coding for the Kunitz-type protease inhibitor domain, which is missing in APP695).
Transcription (found) of APP
10) Confidence 0.59 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.13 Pain Relevance 0.03
In brains of 16 month old APP [V717I] transgenic mice, Cd11b positive and activated microglia cells were predominantly associated with amyloid plaques as revealed by co-staining with A?
Transcription (transgenic mice) of APP in plaques associated with targeted disruption and amyloid plaque
11) Confidence 0.58 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 0.76 Pain Relevance 0.17
derived from the amyloid precursor protein (APP) and of the hyperphosphorylated microtubule-associated protein tau (?).
Transcription (derived) of amyloid precursor protein associated with alzheimer's dementia
12) Confidence 0.56 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.53 Pain Relevance 0.13
derived from the amyloid precursor protein (APP) and of the hyperphosphorylated microtubule-associated protein tau (?).
Transcription (derived) of APP associated with alzheimer's dementia
13) Confidence 0.56 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.53 Pain Relevance 0.13
Indeed transgenic mice overexpressing human amyloid precursor protein (APP) develop early AD-like changes, including diffuse, extracellular A?
Transcription (develop) of amyloid precursor protein associated with targeted disruption, alzheimer's dementia and disease
14) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 1.08 Pain Relevance 0.30
In PC12 cells, APP transcription and secretion have been found to be regulated by NGF and its receptors TrkA and p75: TrkA activation increases APP processing and secretion, while p75 signaling increases APP transcription [117].
Transcription (transcription) of APP
15) Confidence 0.32 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.39 Pain Relevance 0.15
-amyloid formation, at least in the case of some AChEIs (eg, phenserine), does not appear to be associated with cholinesterase inhibition but with a novel mechanism regulating translation of APP mRNA by a putative interleukin-1 or TGF-?
Transcription (translation) of APP associated with alzheimer's dementia
16) Confidence 0.19 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.89 Pain Relevance 0.03
-secretase cleavage site on APP from the A?
Transcription (site) of APP in cleavage
17) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.09 Pain Relevance 0.10
An early and essential phenomenon is the formation of beta-amyloid (?
Transcription (formation) of beta-amyloid associated with alzheimer's dementia
18) Confidence 0.14 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.74 Pain Relevance 0

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