INT178795

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.31
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Zmat3)
Anatomy Link Frequency
plasma 1
liver 1
peritoneal cavity 1
skin 1
neutrophils 1
Zmat3 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 29 100.00 Very High Very High Very High
Inflammation 166 98.92 Very High Very High Very High
antagonist 27 98.24 Very High Very High Very High
Inflammatory response 71 98.00 Very High Very High Very High
imagery 17 90.96 High High
allodynia 4 87.80 High High
agonist 5 81.68 Quite High
cytokine 32 77.20 Quite High
chemokine 79 76.48 Quite High
addiction 4 42.16 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 29 100.00 Very High Very High Very High
Injury 455 99.96 Very High Very High Very High
Urological Neuroanatomy 46 99.68 Very High Very High Very High
INFLAMMATION 237 98.92 Very High Very High Very High
Reperfusion Injury 16 94.56 High High
Neuropathic Pain 6 87.80 High High
Sepsis 12 87.56 High High
Nociception 1 87.04 High High
Peritonitis 34 82.24 Quite High
Necrosis 10 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the majority of wild-type fibers were innervated on average 2 months after transplantation, it seems more likely that re-innervation of the wild-type transplant was fairly complete initially and that denervation occurred subsequently.
Positive_regulation (innervation) of wild-type
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.13 Pain Relevance 0.05
Interestingly, within the span of amino acids that differ between the mutant and wild type proteins, the Cav1.4nob2 channel sequence lacks a putative MAP kinase phosphorylation site that is present in the wild type protein.
Positive_regulation (present) of wild type protein
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
The liver MPO levels of both wild-type and P/I null mice after 90 minutes of ischemia followed by 6 and 15 h of reperfusion were significantly elevated compared to the sham-operated mice at the corresponding time points.
Positive_regulation (elevated) of wild-type in liver associated with ischemia and urological neuroanatomy
3) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 1.03 Pain Relevance 0.30
The plasma ALT levels of both wild-type and P/I null mice after 90 minutes of ischemia followed by 6 and 15 h of reperfusion were significantly elevated when compared to their respective sham-operated mice (Figure 2).
Positive_regulation (elevated) of wild-type in plasma associated with ischemia
4) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.38 Pain Relevance 0.05
The leukocyte influx into the peritoneal cavity consisted predominantly of neutrophils (i.e., 62–80%), which significantly increased in both wild-type and P/I null mice at 6 and 24 hours of CLP.
Positive_regulation (increased) of wild-type in peritoneal cavity
5) Confidence 0.01 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.93 Pain Relevance 0.07
Cold and menthol activate wild-type TRPM8 by shifting its voltage-dependent activation towards more negative potentials [3,6].
Positive_regulation (activate) of wild-type
6) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0.17 Pain Relevance 0.18
Together, the early and late inflammatory clusters comprise 169 genes that are not expressed in unwounded wild-type skin or at early stages of repair but appear to be upregulated in the wild-type wound directly, coincident with the onset of the inflammatory response.
Positive_regulation (upregulated) of wild-type in skin associated with inflammatory response, inflammation and injury
7) Confidence 0.01 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.28 Pain Relevance 0.31
The early inflammatory cluster typically contains genes whose expression is upregulated rapidly in the wild-type, often reaching a peak by 12 hours (Figure 6a), coincident with the influx of neutrophils to the wound site.
Positive_regulation (upregulated) of wild-type in neutrophils associated with inflammation and injury
8) Confidence 0.01 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.39 Pain Relevance 0.33

General Comments

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