INT178799

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.37
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Camp) extracellular region (Camp) cytoplasm (Camp)
Anatomy Link Frequency
CLP 2
Camp (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 70 99.38 Very High Very High Very High
lidocaine 207 99.12 Very High Very High Very High
Inflammation 245 95.80 Very High Very High Very High
cytokine 90 89.00 High High
Inflammatory stimuli 2 82.76 Quite High
anesthesia 4 81.92 Quite High
Inflammatory response 49 63.68 Quite High
alcohol 2 55.76 Quite High
rheumatoid arthritis 1 50.84 Quite High
tolerance 2 49.84 Quite Low
Disease Link Frequency Relevance Heat
Cramps 22 100.00 Very High Very High Very High
Sepsis 130 99.68 Very High Very High Very High
Peritonitis 48 99.64 Very High Very High Very High
Disease 20 98.24 Very High Very High Very High
Leukopenia 6 98.12 Very High Very High Very High
INFLAMMATION 297 95.80 Very High Very High Very High
Apoptosis 42 94.00 High High
Body Weight 5 93.00 High High
Paralysis 1 87.12 High High
Necrosis 8 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among them, CRAMP (cathelin-related anti-microbial peptide), the mouse homolog of anti-microbial protein LL-37, was increased approximately two-fold (Table 1).
Positive_regulation (increased) of CRAMP associated with cramps
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.34 Pain Relevance 0.62
Based on this result, in the rest of experiments, the mice were treated with HCE and killed 12 h after the CLP induction to investigate the mechanisms of protection.


Positive_regulation (induction) of CLP
2) Confidence 0.43 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2571085 Disease Relevance 0.37 Pain Relevance 0.09
The animals were initially divided into 4 groups that were treated by subcutaneous route 6 hours before the CLP induction.
Positive_regulation (induction) of CLP in CLP
3) Confidence 0.29 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2571085 Disease Relevance 0.41 Pain Relevance 0.08
The induction of CLP-induced peritonitis resulted in a significant leukopenia in wild-type as well as P/I null mice as compared to their control counterparts (Table 2).
Positive_regulation (induction) of CLP associated with leukopenia and peritonitis
4) Confidence 0.26 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.63 Pain Relevance 0
For example, CRAMP protein levels were decreased in mice with isoflurane, contrasting with significant increases in CRAMP at 24 h as evoked by lidocaine, compared with mice given zymosan alone.
Positive_regulation (increases) of CRAMP associated with cramps, isoflurane and lidocaine
5) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.96 Pain Relevance 1.02
Mice underwent CLP and 18 hours later received 0.2 ml sc injections of saline (CLP+NS, n = 10) or rHuEPO 400 U/kg (CLP+rHuEPO, n = 14).
Positive_regulation (underwent) of CLP
6) Confidence 0.08 Published 2007 Journal Crit Care Section Body Doc Link PMC2206412 Disease Relevance 0 Pain Relevance 0
Chloroquine demonstrates its positive effects when used prior to the induction of CLP, but also up to 6 hours after [55].
Positive_regulation (induction) of CLP
7) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.84 Pain Relevance 0.15
In a study using the cecal ligation and puncture (CLP) model of polymicrobial sepsis, HMGB-1 levels increased over the span of 1 to 2 days after CLP and remained elevated during the course of disease [17].
Positive_regulation (increased) of CLP in CLP associated with disease and sepsis
8) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.83 Pain Relevance 0.14

General Comments

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