INT178803

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.13
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2)
Anatomy Link Frequency
neutrophils 4
T cells 3
blood 1
endothelium 1
Itgb2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 56 99.12 Very High Very High Very High
chemokine 54 95.84 Very High Very High Very High
ischemia 54 95.36 Very High Very High Very High
Inflammation 84 90.00 High High
psoriasis 44 88.84 High High
Spinal cord 3 83.00 Quite High
Inflammatory response 65 75.92 Quite High
fluoxetine 6 66.20 Quite High
Serotonin 6 64.12 Quite High
antidepressant 18 63.16 Quite High
Disease Link Frequency Relevance Heat
Critical Illness 3 98.44 Very High Very High Very High
Adhesions 174 96.92 Very High Very High Very High
Cv Unclassified Under Development 39 95.36 Very High Very High Very High
Disease 19 92.40 High High
INFLAMMATION 161 90.00 High High
Psoriasis 50 88.84 High High
Viral Meningitis 3 88.84 High High
Stroke 81 86.56 High High
Encephalitis 3 84.44 Quite High
Peritonitis 102 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As LFA-1 expressed in resting naïve T cells exists mainly in inactive low affinity state [6], results that LFA-1 played a key role in the pMV-absorption suggested the transition of LFA-1 to active high affinity state in the course of the pMV-absorption, which could occur via ‘inside-out’ signaling induced by engagement of 2C TCRs with Ld/QL9 (or Ld/P2Ca) complexes [14].
Gene_expression (expressed) of LFA-1 in T cells
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0
HF diet activated expression of genes of endothelium integrins (Itga5, Itga6, Itgam, Itgb1, Itgb2) which participate in cell-matrix interactions.
Gene_expression (expression) of Itgb2 in endothelium
2) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.32 Pain Relevance 0
Neutrophil also express CD11d/CD18 and ?
Gene_expression (express) of CD18 in Neutrophil
3) Confidence 0.40 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.03 Pain Relevance 0.12
2-integrins (eg., CD11b and CD18) expressed on neutrophils has shown to be a critical event mediating stable neutrophil adhesion and migration across the vascular endothelial barrier [26-28].
Gene_expression (expressed) of CD18 in neutrophils associated with adhesions
4) Confidence 0.34 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.25 Pain Relevance 0.08
Neutrophil also express CD11d/CD18 and ?
Gene_expression (/) of CD18 in Neutrophil
5) Confidence 0.34 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.02 Pain Relevance 0.12
In addition, neutrophils also express CD11d/CD18 and ?
Gene_expression (express) of CD18 in neutrophils
6) Confidence 0.34 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.43 Pain Relevance 0.04
Secondly, using 2C T cells deficient in CD28 or LFA-1 expression and mAbs blocking interactions of those receptors with their ligands, it is feasible to probe the contributing roles of TCR/pMHC, CD28/B7-1 and LFA-1/ICAM-1 interactions in the pMV-absorption.

2C T cell absorption of LdB7-1ICAM-1 Dros pMVs

Gene_expression (expression) of LFA-1 in T cell
7) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0
Since LFA-1 is expressed in low-affinity/avidity form in resting naïve T cells [6], the finding that LFA-1 played a pivotal role in the pMV absorption by 2C T cells (Figure 1A) was intriguing and suggested the involvement of ‘inside-out’ signaling evoked by TCR stimulation.
Gene_expression (expressed) of LFA-1 in T cells
8) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0.13
CD18 integrin production can be influenced by cytokines (especially TNF-?)
Gene_expression (production) of CD18 associated with cytokine
9) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.56 Pain Relevance 0.15
T-cells mainly express LFA-1 (CD11a/CD18), which is essential for every step in the process of immune surveillance and mounting an immune response (Dustin et al 2004), namely firm adherence to the wall of blood vessels under blood flow, scanning by T cells of other cells within tissues, and formation of the immunological synapse between T-cells and antigen-presenting cells.
Gene_expression (express) of CD18 in blood
10) Confidence 0.08 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.52 Pain Relevance 0.24

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