INT178812

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 18
Disease Relevance 10.75
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ARC) plasma membrane (ARC) cytoskeleton organization (ARC)
cytoplasm (ARC)
Anatomy Link Frequency
ARC 1
lens 1
body 1
ARC (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 78 97.56 Very High Very High Very High
Arthritis 60 79.68 Quite High
Bile 4 64.80 Quite High
cytokine 1 50.32 Quite High
vagus nerve 2 41.84 Quite Low
anesthesia 13 5.00 Very Low Very Low Very Low
backache 6 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 951 100.00 Very High Very High Very High
Toxicity 65 99.00 Very High Very High Very High
Nicotine Addiction 117 97.16 Very High Very High Very High
Shock 1 95.92 Very High Very High Very High
Body Weight 5 82.20 Quite High
Cataract 338 81.52 Quite High
Arthritis 60 79.68 Quite High
Obesity 14 70.32 Quite High
Insulin Resistance 3 68.44 Quite High
Ulcers 1 62.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multivariate logistic regression models and prevalence odds ratios (PORs) with 95% confidence intervals (CIs) were used to examine, separately and jointly, the associations between ARC and covariables, such as age (as a continuous variable), sex, current smoking habit (yes vs. no), and alcohol consumption (yes vs. no).
ARC Binding (associations) of associated with nicotine addiction, aids-related complex and alcohol
1) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.46 Pain Relevance 0.08
We observed no associations between P-Hg and ARC.
ARC Neg (no) Binding (associations) of associated with aids-related complex
2) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.78 Pain Relevance 0.03
Some epidemiological studies have indicated that Se status is negatively associated with ARC (Karaküçük et al. 1995; Valero et al. 2002), whereas one study observed a positive association with B-Se (Jacques et al. 1988).
ARC Binding (associated) of associated with aids-related complex
3) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.51 Pain Relevance 0
As a first step, we shall identify all publications in the relevant period from the principal investigators awarded ARC funds.
ARC Binding (funds) of associated with aids-related complex
4) Confidence 0.32 Published 2004 Journal Health Res Policy Syst Section Body Doc Link PMC503400 Disease Relevance 0.23 Pain Relevance 0
Most of the issues are internal to the scientific world, but there is still a key interface between individual researchers and ARC as the research-funding body.
ARC Binding (interface) of in body associated with aids-related complex
5) Confidence 0.32 Published 2004 Journal Health Res Policy Syst Section Body Doc Link PMC503400 Disease Relevance 0.31 Pain Relevance 0
It can be important to consider not only the financial inputs, including any beyond the specific ARC funding, but also the experience of the research team and the knowledge base on which they built.
ARC Binding (funding) of associated with aids-related complex
6) Confidence 0.32 Published 2004 Journal Health Res Policy Syst Section Body Doc Link PMC503400 Disease Relevance 0.59 Pain Relevance 0.04
ARC was strongly associated with B-Hg exposure among those with P-Se status < 110 ?
ARC Binding (associated) of associated with aids-related complex
7) Confidence 0.32 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.68 Pain Relevance 0
In the present study, it is not clear whether the Se association with ARC was independent of Hg-related lens damage.
ARC Spec (whether) Binding (association) of in lens associated with aids-related complex
8) Confidence 0.32 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.68 Pain Relevance 0
In a multivariate model that included all the covariables above, only age was significantly associated with ARC (POR = 1.23; 95% CI, 1.16–1.30).
ARC Binding (associated) of associated with aids-related complex
9) Confidence 0.32 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.74 Pain Relevance 0.08
On the other hand, P-Se was the Se biomarker that was most strongly associated ARC prevalence.
ARC Binding (associated) of associated with aids-related complex
10) Confidence 0.31 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.46 Pain Relevance 0
B-Hg was more strongly associated with ARC than was P-Hg.
ARC Binding (associated) of associated with aids-related complex
11) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.49 Pain Relevance 0
It is noteworthy that the adjusted POR (95% CI) is 13.5 (2.23–81.6) when comparing persons with low P-Se–high B-Hg and persons with low P-Se–low B-Hg, and 5.09 (1.67–15.1) when comparing persons with low P-Se–high B-Hg and persons with high P-Se–high B-Hg, revealing a significant association between ARC and B-Hg when P-Se is low, and a significant association between ARC and P-Se when B-Hg is high.
ARC Binding (association) of associated with aids-related complex
12) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.94 Pain Relevance 0
B-Hg was positively associated with ARC at the second and third versus first quartiles; although the POR for fourth versus first B-Hg quartile was elevated, it was not statistically significant and was lower than the other effect estimates.
ARC Binding (associated) of associated with aids-related complex
13) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.76 Pain Relevance 0.07
We observed no associations between ARC and the other covariables.
ARC Neg (no) Binding (associations) of associated with aids-related complex
14) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.73 Pain Relevance 0.09
It is noteworthy that the adjusted POR (95% CI) is 13.5 (2.23–81.6) when comparing persons with low P-Se–high B-Hg and persons with low P-Se–low B-Hg, and 5.09 (1.67–15.1) when comparing persons with low P-Se–high B-Hg and persons with high P-Se–high B-Hg, revealing a significant association between ARC and B-Hg when P-Se is low, and a significant association between ARC and P-Se when B-Hg is high.
ARC Binding (association) of associated with aids-related complex
15) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.92 Pain Relevance 0
The literature on the association between Se and ARC in human populations is inconsistent.
ARC Binding (association) of associated with aids-related complex
16) Confidence 0.27 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.68 Pain Relevance 0
In addition to the acid resistance gene cluster, the L. hongkongensis genome contains two arc gene clusters [arcA (LHK_02729 and LHK_02734), arcB (LHK_02728 and LHK_02733), arcC (LHK_02727 and LHK_02732) and arcD (LHK_02730 and LHK_02731)] of the arginine deiminase pathway which converts L-arginine to carbon dioxide, ATP, and ammonia.
arc Binding (contains) of associated with aids-related complex
17) Confidence 0.05 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2652115 Disease Relevance 0.26 Pain Relevance 0.06
Brain-specific insulin receptors, involved in energy homeostasis regulation, are mainly located in the area of the medio-basal hypothalamus, the portion that includes the arcuate nucleus (ARC).35 Insulin binds to its receptor and generates signal transduction by the intracellular signaling pathway known as insulin receptor substrate phosphatidylinositol 3-kinase (IRS/PI 3-kinase).36 Basically, insulin binds to the extracellular domain of its receptor and activates tyrosine kinase activity, thereby creating a binding site for different isoforms of the IRS protein family.37,38 The IRS isoforms that become phosphorylated act as docking proteins for several proteins including PI 3-kinase.39 Notably, a part of leptin signal transduction in hypothalamic key areas is also using IRS/ PI 3-kinase.40,41
ARC Binding (binds) of in ARC associated with aids-related complex
18) Confidence 0.04 Published 2007 Journal Obes Surg Section Body Doc Link PMC2798024 Disease Relevance 0.52 Pain Relevance 0.03

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