INT178818

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.98
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
brain 4
peritoneal macrophages 2
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 119 99.92 Very High Very High Very High
cytokine 61 87.72 High High
reflex sympathetic dystrophy 3 84.56 Quite High
chemokine 28 82.52 Quite High
fibrosis 1 69.04 Quite High
Antinociceptive 2 54.44 Quite High
medulla 1 49.08 Quite Low
anesthesia 9 46.40 Quite Low
cva 4 33.16 Quite Low
isoflurane 1 17.12 Low Low
Disease Link Frequency Relevance Heat
Injury 181 99.92 Very High Very High Very High
INFLAMMATION 141 99.92 Very High Very High Very High
Nociception 13 99.00 Very High Very High Very High
Closed Head Injuries 44 98.88 Very High Very High Very High
Targeted Disruption 19 90.24 High High
Complex Regional Pain Syndromes 3 83.92 Quite High
Bone Fracture 3 81.04 Quite High
Fibrosis 2 69.04 Quite High
Sprains And Strains 4 58.24 Quite High
Disease 5 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The experimental part of the study was set-up on two different protocols with the aim to assess the TNF-dependent regulation of IL-18 in the murine brain:

(1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of CHI, using mice double-deficient in genes for TNF and lymphotoxin-?

Spec (investigate) Regulation (regulation) of Gene_expression (expression) of IL-18 in brain associated with closed head injuries
1) Confidence 0.40 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.47 Pain Relevance 0.03
The experimental part of the study was set-up on two different protocols with the aim to assess the TNF-dependent regulation of IL-18 in the murine brain:

(1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of CHI, using mice double-deficient in genes for TNF and lymphotoxin-?

Regulation (intracranial) of Gene_expression (expression) of IL-18 in brain associated with closed head injuries
2) Confidence 0.40 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.47 Pain Relevance 0.03
Adoptive transfer of the peritoneal macrophages deficient in IL-18 reversed the protection against ischemic AKI to the same degree as wild type macrophages suggesting that ischemic AKI is independent of IL-18 production by macrophages [40].
Neg (independent) Regulation (independent) of Gene_expression (production) of IL-18 in peritoneal macrophages associated with injury
3) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.03 Pain Relevance 0.03
Our results also refute that the pro-nociceptive role of caspase-1 in carrageenin inflammation is dependent on its capacity to process IL-18.
Regulation (dependent) of Gene_expression (process) of IL-18 associated with nociception and inflammation
4) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 1.02 Pain Relevance 0.59

General Comments

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