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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2004
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Il18) extracellular region (TNF, Il18) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
brain 2
TNF (Homo sapiens)
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 53.20 Quite High
anesthesia 4 46.40 Quite Low
cva 2 33.72 Quite Low
Inflammatory mediators 3 10.08 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Closed Head Injuries 22 98.88 Very High Very High Very High
Targeted Disruption 3 90.24 High High
Sprains And Strains 2 58.24 Quite High
Disease 1 53.68 Quite High
INFLAMMATION 13 53.20 Quite High
Necrosis 4 50.00 Quite Low
Cancer 4 50.00 Quite Low
Injury 9 41.20 Quite Low
Cv General 3 Under Development 2 33.72 Quite Low
Coma 1 28.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The experimental part of the study was set-up on two different protocols with the aim to assess the TNF-dependent regulation of IL-18 in the murine brain:

(1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of CHI, using mice double-deficient in genes for TNF and lymphotoxin-?

TNF-dependent Spec (investigate) Regulation (regulation) of Gene_expression (expression) of IL-18 in brain associated with closed head injuries
1) Confidence 0.18 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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