INT178823

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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2004
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.28
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Il18) extracellular region (TNF, Il18) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
brain 2
head 1
TNF (Homo sapiens)
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 32 95.60 Very High Very High Very High
Inflammatory mediators 12 95.16 Very High Very High Very High
Inflammation 36 76.24 Quite High
Inflammatory response 4 75.12 Quite High
intrathecal 16 74.56 Quite High
cva 8 66.72 Quite High
anesthesia 16 32.64 Quite Low
Intracerebroventricular 8 5.00 Very Low Very Low Very Low
Neurobehavioral 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 36 98.04 Very High Very High Very High
Closed Head Injuries 88 96.80 Very High Very High Very High
INFLAMMATION 52 94.76 High High
Brain Injury 44 90.44 High High
Necrosis 16 81.00 Quite High
Cancer 16 80.64 Quite High
Coma 4 76.64 Quite High
Targeted Disruption 12 76.48 Quite High
Cv General 3 Under Development 8 66.72 Quite High
Disease 4 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the second part of the study, the potential TNF-dependent regulation of intracerebral IL-18 levels was further characterized in an experimental set-up in mice: (1) in a standardized model of CHI in TNF/lymphotoxin-?
TNF-dependent Regulation (regulation) of IL-18 associated with closed head injuries
1) Confidence 0.18 Published 2004 Journal J Neuroinflammation Section Abstract Doc Link PMC506787 Disease Relevance 0.87 Pain Relevance 0.08
The experimental part of the study was set-up on two different protocols with the aim to assess the TNF-dependent regulation of IL-18 in the murine brain:

(1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of CHI, using mice double-deficient in genes for TNF and lymphotoxin-?

TNF-dependent Regulation (regulation) of IL-18 in brain associated with closed head injuries
2) Confidence 0.18 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.29 Pain Relevance 0.03
However, the TNF-dependent regulation of IL-18 in the injured brain has not yet been investigated.
TNF-dependent Spec (investigated) Regulation (regulation) of IL-18 in brain
3) Confidence 0.18 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 1.26 Pain Relevance 0.25
The present study was designed to assess a potential regulation of intracranial IL-18 levels by TNF based on a clinical study in head-injured patients and an experimental model in mice.
TNF Regulation (regulation) of IL-18 in head
4) Confidence 0.18 Published 2004 Journal J Neuroinflammation Section Abstract Doc Link PMC506787 Disease Relevance 0.87 Pain Relevance 0.05

General Comments

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