INT178828

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 16.10
Pain Relevance 15.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neck 1
immune cells 1
nerve 1
neurons 1
forebrain 1
Pain1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1386 100.00 Very High Very High Very High
Neuropathic pain 140 100.00 Very High Very High Very High
Lasting pain 132 100.00 Very High Very High Very High
IPN 70 100.00 Very High Very High Very High
withdrawal 18 100.00 Very High Very High Very High
Chronic low back pain 12 99.66 Very High Very High Very High
allodynia 45 98.68 Very High Very High Very High
GCH1 12 98.64 Very High Very High Very High
nociceptor 271 98.32 Very High Very High Very High
Osteoarthritis 70 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1540 100.00 Very High Very High Very High
Neuropathic Pain 202 100.00 Very High Very High Very High
Inflammatory Pain 70 100.00 Very High Very High Very High
Neck Pain 3 99.78 Very High Very High Very High
Low Back Pain 22 99.66 Very High Very High Very High
Sprains And Strains 30 98.46 Very High Very High Very High
Nociception 96 98.26 Very High Very High Very High
Knee Osteoarthritis 65 98.20 Very High Very High Very High
Nervous System Injury 18 97.66 Very High Very High Very High
Targeted Disruption 88 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only a few of the previously published studies have presented information on longitudinal variation in pain and function in the natural history of knee OA.
Regulation (information) of pain in knee associated with pain and osteoarthritis
1) Confidence 0.14 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC509423 Disease Relevance 1.71 Pain Relevance 0.68
To that end, we used the spared nerve injury model (SNI) [32] and measured the heightened pain sensitivity in which normally innocuous tactile stimuli illicit a pain withdrawal response, a phenomenon termed mechanical allodynia that is a hallmark of neuropathic pain [8].
Regulation (response) of pain in nerve associated with pain, nervous system injury, allodynia, neuropathic pain and withdrawal
2) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.26 Pain Relevance 1.22
Alternatively, TrkA-signaling may operate in immune cells to control inflammatory pain, and those cells were untouched by Nav1.8Cre [38].
Regulation (control) of pain in immune cells associated with ipn
3) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.16 Pain Relevance 1.17
Interestingly, behavioral analyses showed that preferential defect in Runx1-persistent nociceptors in these late knockouts led to a selective impairment of inflammatory pain without affecting neuropathic pain.
Neg (without) Regulation (affecting) of pain in nociceptors associated with ipn, nociceptor and neuropathic pain
4) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.16 Pain Relevance 1.37
Contrary to this, Johnston et al., [34] found office workers with neck pain showed no difference in pressure pain thresholds (PPT) over the neck muscles in comparison to controls but they did have lower PPT at median nerve and tibialis anterior sites.
Neg (no) Regulation (difference) of pain in neck associated with pain and neck pain
5) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2825226 Disease Relevance 1.31 Pain Relevance 1.55
Analyses investigating the moderating effect of chronic pain complaints on the effect of the BDNF Met allele, revealed a significant interaction between pain status and the BDNF Met allele in the model of the P1- component of Fz (B?
Spec (investigating) Regulation (effect) of pain associated with pain and lasting pain
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.96 Pain Relevance 0.96
This influence of chronic pain complaints on gene expression possibly implicates epigenetic modification.



Spec (possibly) Regulation (influence) of pain associated with lasting pain
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.43 Pain Relevance 0.43
More specifically, we expected significant interaction effects between the polymorphisms and pain status (chronic low back pain patients versus pain free controls).


Regulation (controls) of pain associated with low back pain, chronic low back pain and pain
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.90 Pain Relevance 0.89
The variable pain status refers to the chronic pain patients versus pain free controls.
Regulation (controls) of pain associated with pain and lasting pain
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.70 Pain Relevance 0.73
In this review we focus on genetic approaches to the mechanisms involved in
               activating nociceptive neurons, human genetics of pain perception, and genetic
               validation of pain targets leading to new drugs. 
Regulation (targets) of pain in neurons associated with nociception and pain
10) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.08 Pain Relevance 0.93
Examples of transgenics that have generated
               insights into pain pathways are numerous, and include reports of modulation of pain
               behaviour by the overexpression of the neuropeptide galanin [28], and the enhancement of
               inflammatory pain by overexpression of the NMDA receptor subunit N2RB in the
               forebrain [29]. 
Regulation (modulation) of pain in forebrain associated with pain, nmda receptor, ipn and neuropeptide
11) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.18 Pain Relevance 0.83
Interestingly, not all genetic variations affect all pain modalities, meaning that
               these must be transduced by distinct pathways. 
Neg (not) Regulation (affect) of pain associated with pain
12) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.54 Pain Relevance 1.46
Strain differences can also be used to map quantitative trait loci
               affecting pain thresholds.
Regulation (affecting) of pain associated with pain and sprains and strains
13) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.74 Pain Relevance 1.18
Subjects heterozygous or
               homozygous for the pain-protective haplotype were found to show reduced upregulation
               of the GCH1 transcript in response to cAMP, resulting in lower
               levels of BH4, suggesting that altered GCH1 transcriptional
               modulation underlies the decreased pain sensitivity observed in these individuals.
Regulation (sensitivity) of pain associated with pain and gch1
14) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.76 Pain Relevance 1.17
In contrast, some rare recessive
               conditions found in societies that practice consanguineous marriage lead to
               alterations in pain thresholds, and the genes that underlie such conditions are of
               major interest. 
Regulation (alterations) of pain associated with pain
15) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.21 Pain Relevance 1.06

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