INT178830

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 7.63
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MR1) endoplasmic reticulum (MR1) plasma membrane (MR1)
Anatomy Link Frequency
ventricle 1
long bones 1
articular cartilage 1
leaflets 1
MR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 126 100.00 Very High Very High Very High
iatrogenic 1 78.44 Quite High
Osteoarthritis 75 72.08 Quite High
antagonist 3 51.52 Quite High
aspirin 9 50.20 Quite High
Inflammation 33 39.52 Quite Low
Snapping jaw 2 32.00 Quite Low
cINOD 11 17.76 Low Low
COX-2 inhibitor 9 9.76 Low Low
anesthesia 21 6.04 Low Low
Disease Link Frequency Relevance Heat
Mitral Valve Insufficiency 359 100.00 Very High Very High Very High
Stroke 14 98.60 Very High Very High Very High
Congenital Anomalies 16 96.32 Very High Very High Very High
Chronic Renal Failure 15 92.28 High High
Arrhythmias 2 Under Development 16 92.04 High High
Autoimmune Disease 3 91.40 High High
Cirrhosis 7 90.60 High High
Sepsis 10 90.52 High High
Wound Infection 10 90.00 High High
Scoliosis 2 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primary efficacy endpoint was acute device success defined as clip implant with reduction of MR to ?
Negative_regulation (reduction) of MR associated with mitral valve insufficiency
1) Confidence 0.50 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2878966 Disease Relevance 0.96 Pain Relevance 0
Given that certain leaflet anatomy is deemed to hamper a proper clip positioning on the leaflets with sufficient reduction in MR, echocardiographic criteria played a crucial role among clinical considerations for patient selection.
Negative_regulation (reduction) of MR in leaflets associated with mitral valve insufficiency
2) Confidence 0.50 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2878966 Disease Relevance 0.66 Pain Relevance 0.05
Reductions on MR were achieved in all patients, with 68% of patients who met the procedural goal of reducing MR to mild (1+) or less and 97% of patients with MR ?
Negative_regulation (reducing) of MR associated with mitral valve insufficiency
3) Confidence 0.37 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2878966 Disease Relevance 0.51 Pain Relevance 0
However, both pacemaker and MR technology are continually developing and there are times when MR is needed to provide valuable clinical information in patients with pacemakers.
Negative_regulation (needed) of MR
4) Confidence 0.33 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0 Pain Relevance 0.04
Dobutamine infusion has the ability to decrease MR volume due to a reduction of afterload and mitral orifice size that may occur as a result of the vasodilatory and inotropic effects of dobutamine [35,36].
Negative_regulation (decrease) of MR associated with mitral valve insufficiency
5) Confidence 0.16 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC514499 Disease Relevance 1.03 Pain Relevance 0
Therefore, if during dobutamine protocol we find myocardial viability and a concomitant reduction of MR, these results should be interpreted with caution because we cannot assume a direct effect of the presence of myocardial viability on the MR.
Negative_regulation (reduction) of MR associated with mitral valve insufficiency
6) Confidence 0.16 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC514499 Disease Relevance 0.98 Pain Relevance 0
Patients with presence of contractile reserve show a decrease in MR [32], whereas generally a fall in stroke volume is associated with an increase in mitral regurgitant volume during isometric exercise, which increases systemic resistances and thereby afterload [33].
Negative_regulation (decrease) of MR associated with stroke and mitral valve insufficiency
7) Confidence 0.16 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC514499 Disease Relevance 1.21 Pain Relevance 0
The multicenter AMADEUS trial suggested an acute reduction in MR by a mean of 1 grade with the modified CARILLON XE device [69, 70].
Negative_regulation (reduction) of MR associated with mitral valve insufficiency
8) Confidence 0.16 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2926577 Disease Relevance 0.26 Pain Relevance 0
The reduction of the MR severity is real-time assessed and, if necessary, it may be repositioned to reduce MR further.
Negative_regulation (reduce) of MR associated with mitral valve insufficiency
9) Confidence 0.16 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2926577 Disease Relevance 0.44 Pain Relevance 0.05
Other techniques are based on the concept of moving the ventricle, rather than the annulus, to increase leaflet coaptation and eliminate functional MR.
Negative_regulation (eliminate) of MR in ventricle associated with mitral valve insufficiency
10) Confidence 0.11 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2926577 Disease Relevance 0.26 Pain Relevance 0
The reduction of the MR severity is real-time assessed and, if necessary, it may be repositioned to reduce MR further.
Negative_regulation (reduction) of MR associated with mitral valve insufficiency
11) Confidence 0.11 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2926577 Disease Relevance 0.44 Pain Relevance 0.04
The affected metaphyses of long bones may show horizontal or longitudinal areas of signal loss of on T1- and T2-weighted MR images, which resemble metaphyseal bands and striations seen on conventional radiographs [47].
Negative_regulation (loss) of MR in long bones
12) Confidence 0.07 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.35 Pain Relevance 0
Moreover, cell perimeter is significantly increased when cells were cultured in the presence of HNE-modified Col II at a 1:20 MR compared to the control (Figure 2c), but decreased in the presence of HNE-modified Col II at a 1:200 MR.
Negative_regulation (decreased) of MR
13) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.13 Pain Relevance 0.04
In the same way, the circularity index of the cells is reduced in the presence of HNE-modified Col II at a 1:20 MR and increased then after in the presence of HNE-modified Col II at a 1:200 MR (Figure 2d).
Negative_regulation (reduced) of MR
14) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.19 Pain Relevance 0.03
Thus, in general clinical treatments, the mixture of compounds might be effective in a quite broad region of MR/ER (about 0.001 to 1,000).
Negative_regulation (region) of MR
15) Confidence 0.02 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0 Pain Relevance 0
Observation of the mandibular condyle articular cartilage displayed an increase in thickness with TR and a decrease in thickness with MR.
Negative_regulation (decrease) of MR in articular cartilage
16) Confidence 0.02 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2703201 Disease Relevance 0.06 Pain Relevance 0
In real-time MR, the imaging matrix (and thus spatial resolution) is reduced in size to support an imaging speed between 5 and 10 frames per second [4].
Negative_regulation (reduced) of MR associated with imagery
17) Confidence 0.02 Published 2008 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2637847 Disease Relevance 0.15 Pain Relevance 0.18

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