INT178841

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 10.35
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mRNA processing (SNRNP70) RNA binding (SNRNP70)
nucleus (SNRNP70)
Anatomy Link Frequency
glands 2
blood 1
SNRNP70 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 11 99.08 Very High Very High Very High
rheumatoid arthritis 52 98.00 Very High Very High Very High
Analgesic 71 97.68 Very High Very High Very High
member 8 1 96.84 Very High Very High Very High
imagery 25 93.80 High High
antidepressant 4 90.44 High High
aspirin 6 78.40 Quite High
monoamine 2 76.08 Quite High
Inflammation 60 74.88 Quite High
Osteoarthritis 112 63.64 Quite High
Disease Link Frequency Relevance Heat
Frailty 196 99.40 Very High Very High Very High
Familial Combined Hyperlipidemia 127 99.36 Very High Very High Very High
Apoptosis 36 99.36 Very High Very High Very High
Diabetes Mellitus 206 98.68 Very High Very High Very High
Infection 66 98.60 Very High Very High Very High
Thyroid Disease 34 98.32 Very High Very High Very High
Rheumatoid Arthritis 59 98.00 Very High Very High Very High
Nasopharynx Cancer 103 96.48 Very High Very High Very High
Genetic Predisposition To Disease 8 96.28 Very High Very High Very High
Disorder Of Lipid Metabolism 94 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional SNPs were added from a) LDselect analysis of resequencing information from the SeattleSNPs project if available (Carlson et al. 2004; Nickerson 2003); b) nonsynonymous SNPs from dbSNP release 124 (National Center for Biotechnology Information 2005); and c) SNPs with prior reports of association proposed by a MESA investigator.


Localization (release) of SNP associated with increased venous pressure under development
1) Confidence 0.78 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920916 Disease Relevance 0.10 Pain Relevance 0
Additional SNPs were added from a) LDselect analysis of resequencing information from the SeattleSNPs project if available (Carlson et al. 2004; Nickerson 2003); b) nonsynonymous SNPs from dbSNP release 124 (National Center for Biotechnology Information 2005); and c) SNPs with prior reports of association proposed by a MESA investigator.


Localization (release) of SNP associated with increased venous pressure under development
2) Confidence 0.78 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920916 Disease Relevance 0.10 Pain Relevance 0
Based on the above sequencing data, linkage disequilibrium analysis results showed that all detected SNPs located in the same haploblock (Figure 1).
Localization (located) of SNP
3) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2838785 Disease Relevance 0.24 Pain Relevance 0
We find a set of SNPs which are strongly associated with both ATD and RA but when we look at the allele-specific genotype counts for these loci, we see that while one of the alleles is more common in RA patients, the other is more common in ATD patients.
Localization (set) of SNP associated with thyroid disease and rheumatoid arthritis
4) Confidence 0.73 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 2.16 Pain Relevance 0.40
To address this possibility, we looked for an association between SNP variants and TST immobility for known coding SNPs in Tph2, Slc6a4, all serotonin receptors, and the genes for corticotrophin releasing hormone (Crh) and the Crh receptors.
Localization (immobility) of SNP associated with serotonin
5) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.59 Pain Relevance 0.37
The structures were aligned using YASARA [23] and the location of the SNP was marked with yellow.
Localization (location) of SNP
6) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0 Pain Relevance 0
We defined a domain distortion (DD) parameter as the ratio of the difference in the matching score (due to the presence of the SNP) to the matching score of the sequence without the SNP.
Localization (presence) of SNP
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0 Pain Relevance 0
For example, the transcription factor TCF3 has 44 known binding partners, and links to 19 of these partners could be broken due to the presence of the domain-altering SNP.
Localization (presence) of SNP
8) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0.58 Pain Relevance 0
We made similar observations in the present investigation, as both the Ach and SNP responses were blunted in the presence of NIDDM.
Localization (responses) of SNP associated with diabetes mellitus
9) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.59 Pain Relevance 0.09
High-throughput localization of SNP distribution is inarguably efficient, but the vast majority of SNPs reside outside coding regions.
Localization (localization) of SNP
10) Confidence 0.12 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
LD analysis of SNP distribution in haplotypes defined by maximum likelihood methods has revealed genomic structures similar to and yet far less complex than those identified by allele variants haplotyped by segregation analysis [1-6,24].
Localization (distribution) of SNP
11) Confidence 0.11 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
These results are consistent with studies showing that SNP, SNAP, and L-arginine inhibited histamine-stimulated acid secretion from gastric glands isolated from animals [13,15].
Localization (secretion) of SNP in glands
12) Confidence 0.10 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
It is known that SNP releases NO [26], and in our experiments SNP reduced secretion of gastric acid from isolated glands.
Neg (NO) Localization (releases) of SNP in glands
13) Confidence 0.10 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
One might infer that the G-1250A SNP in the putative regulatory region could be related to some moderate functional alteration, and the ?
Localization (related) of G-1250A SNP
14) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738941 Disease Relevance 0 Pain Relevance 0.66
A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

We hypothesized that a common SNP in the 3' untranslated region of the upstream transcription factor 1 (USF1), rs3737787, may affect lipid traits by influencing gene expression levels, and we investigated this possibility utilizing the Mexican population, which has a high predisposition to dyslipidemia.

Localization (region) of SNP associated with familial combined hyperlipidemia
15) Confidence 0.08 Published 2009 Journal PLoS Genetics Section Title Doc Link PMC2730565 Disease Relevance 0.66 Pain Relevance 0
The mechanism by which rs4804803 SNP influences DEN replication in MDDCs is currently unknown.
Localization (replication) of SNP
16) Confidence 0.07 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.65 Pain Relevance 0
In each case of UCP2 SNP all three possible models (additive, dominant and recessive) were tested and the best fitted one was chosen by the higher R2 of the test.
Localization (case) of SNP
17) Confidence 0.06 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.12 Pain Relevance 0
SNP array) and the vast resources created by Human Genome Project will lead to
Localization (created) of SNP
18) Confidence 0.06 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.76 Pain Relevance 0
0.0009), for a SNP (rs2619641) located within the intronic sequences of K+ large conductance Ca2+-activated channel, subfamily M alpha member 1 (KCNMA1) at10q22.
Localization (located) of SNP associated with member 8
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.05 Pain Relevance 0.10
SNP rs8014194, located within the CLMN gene on chromosome 14, was strongly associated with statin-mediated change in total cholesterol with an 84% probability by Bayesian analysis, and a p-value exceeding conventional levels of genome-wide significance by frequentist analysis (P?
Localization (located) of SNP associated with disorder of lipid metabolism
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2842298 Disease Relevance 0.31 Pain Relevance 0.04

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