INT17885

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Context Info
Confidence 0.56
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.74
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (YWHAZ) mitochondrion (YWHAZ) protein complex (YWHAZ)
cytoplasm (YWHAZ) cytosol (YWHAZ) signal transduction (YWHAZ)
Anatomy Link Frequency
macrophages 1
PMNL 1
YWHAZ (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C inhibitor 1 99.70 Very High Very High Very High
Osteoarthritis 26 99.60 Very High Very High Very High
Inflammation 105 99.38 Very High Very High Very High
corticosteroid 17 98.78 Very High Very High Very High
cINOD 35 87.84 High High
rheumatoid arthritis 88 87.80 High High
Kinase C 5 82.56 Quite High
methotrexate 4 80.40 Quite High
cOX1 1 78.88 Quite High
COX2 2 78.24 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 29 99.60 Very High Very High Very High
INFLAMMATION 104 99.38 Very High Very High Very High
Increased Venous Pressure Under Development 4 92.96 High High
Toxicity 4 92.20 High High
Miosis 8 91.64 High High
Stress 7 89.36 High High
Rheumatoid Arthritis 91 87.80 High High
Ocular Hypertension 10 87.24 High High
Macular Edema 98 81.52 Quite High
Pressure And Volume Under Development 12 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein kinase C inhibitor, H-7, and the phospholipase A2 inhibitor, BPB, both prevented drug-mediated activation of superoxide generation by PMNL.
Negative_regulation (inhibitor) of phospholipase A2 in PMNL associated with kinase c inhibitor
1) Confidence 0.56 Published 1991 Journal Agents Actions Section Abstract Doc Link 1950816 Disease Relevance 0.08 Pain Relevance 0.17
The CT results demonstrated a notable decrease in gene expression for B2M and YWHAZ from the OA sample group (Figure 2).
Negative_regulation (decrease) of YWHAZ associated with osteoarthritis
2) Confidence 0.34 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.37 Pain Relevance 0.19
Their tropism for lysosomes [172] is probably the cause for their slow accumulation in macrophages, in which they inhibit the release of arachidonate and the production of prostaglandin E2 via phospholipase A2 inhibition [173].
Negative_regulation (inhibition) of phospholipase A2 in macrophages
3) Confidence 0.04 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.67 Pain Relevance 0.60
Corticosteroids, the potent anti-inflammatory agents elicit their action by blocking the enzyme phospholipase A2 to inhibit arachidonic acid production, thereby preventing the synthesis of all the PGs, thromboxanes and eicosanoids.
Negative_regulation (blocking) of phospholipase A2 associated with corticosteroid and inflammation
4) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751374 Disease Relevance 1.07 Pain Relevance 0.52
For example, studies in which the release of endogenous AA was attenuated by inhibiting PLA2 (phospholipase A2) activity, revealed a significant reduction in GSIS from human islets [39].
Negative_regulation (inhibiting) of phospholipase A2
5) Confidence 0.03 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.09 Pain Relevance 0
Steroids also inhibit the production of prostaglandins, but at a higher level in the biochemical pathway, by inhibiting the enzyme phospholipase A2, which catalyses the conversion of membrane lipids to arachidonic acid.
Negative_regulation (inhibiting) of phospholipase A2
6) Confidence 0.02 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699812 Disease Relevance 0.47 Pain Relevance 0.10

General Comments

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