INT17886

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 95
Total Number 97
Disease Relevance 70.91
Pain Relevance 31.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 4
microglia 4
chondrocytes 2
cartilage 2
joint 2
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2032 100.00 Very High Very High Very High
Arthritis 1650 100.00 Very High Very High Very High
cytokine 1398 100.00 Very High Very High Very High
Potency 143 99.92 Very High Very High Very High
anakinra 404 99.90 Very High Very High Very High
Osteoarthritis 360 99.84 Very High Very High Very High
Pain threshold 1 99.84 Very High Very High Very High
bradykinin 7 99.82 Very High Very High Very High
Pain 236 99.80 Very High Very High Very High
antagonist 320 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2373 100.00 Very High Very High Very High
Arthritis 1597 100.00 Very High Very High Very High
Crystal Associated Disease 1411 100.00 Very High Very High Very High
Keratitis 138 100.00 Very High Very High Very High
Injury 407 99.90 Very High Very High Very High
Osteoarthritis 339 99.84 Very High Very High Very High
Pain 195 99.84 Very High Very High Very High
Rheumatoid Arthritis 836 99.74 Very High Very High Very High
Periodontitis 8 99.72 Very High Very High Very High
Colitis 64 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further diminish IL1?
Negative_regulation (diminish) of IL1
1) Confidence 0.57 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.78 Pain Relevance 0.51
By contrast, the NSAIDs were found to be less effective in suppressing the IL-1 accelerated disease in mice.
Negative_regulation (suppressing) of IL-1 associated with cinod and disease
2) Confidence 0.56 Published 1991 Journal Agents Actions Section Abstract Doc Link 1950817 Disease Relevance 1.05 Pain Relevance 0.72
CONCLUSIONS: IL1 inhibition both prevented and relieved pain and ankle joint inflammation in response to intra-articular MSU crystals in mice.
Negative_regulation (inhibition) of IL1 in articular
3) Confidence 0.42 Published 2009 Journal Ann. Rheum. Dis. Section Body Doc Link 19528034 Disease Relevance 0.05 Pain Relevance 0
The effects of IL1 inhibition were determined in this model, and in the comparator models of crystal-induced peritonitis and subcutaneous air pouch inflammation.
Negative_regulation (inhibition) of IL1
4) Confidence 0.42 Published 2009 Journal Ann. Rheum. Dis. Section Body Doc Link 19528034 Disease Relevance 0.24 Pain Relevance 0
However, consequences of IL1 inhibition have not been explored in more clinically relevant models of crystal-induced arthritis.
Negative_regulation (inhibition) of IL1 associated with arthritis
5) Confidence 0.42 Published 2009 Journal Ann. Rheum. Dis. Section Abstract Doc Link 19528034 Disease Relevance 0.58 Pain Relevance 0.25
Moreover, acute administration of IL-1ra in wild type mice, either immediately following the cessation of acute morphine analgesia, or following the development of chronic morphine tolerance, re-instated the analgesia, suggesting that blockade of the IL-1 system unmasks the analgesic effect of morphine.
Negative_regulation (blockade) of IL-1 associated with analgesic, tolerance, analgesia and morphine
6) Confidence 0.42 Published 2005 Journal Pain Section Abstract Doc Link 15836969 Disease Relevance 0.20 Pain Relevance 2.25
activity prevents diet-induced diabetes in P. obesus and inhibits IL-1?
Negative_regulation (inhibits) of IL-1 associated with diabetes mellitus
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2952629 Disease Relevance 0.65 Pain Relevance 0
Another hallmark of anti-inflammatory response in the CTX treated mice is the down-regulation of IL1?
Negative_regulation (regulation) of IL1 associated with inflammatory response
8) Confidence 0.42 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.89 Pain Relevance 0.46
-inhibitor (0,5 or 0,1 mM) before IL-1?
Negative_regulation (inhibitor) of IL-1
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952629 Disease Relevance 0.19 Pain Relevance 0.06
-inhibitor (0,1 mM) before IL-1?
Negative_regulation (inhibitor) of IL-1
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952629 Disease Relevance 0.06 Pain Relevance 0
Nonsteroidal anti-inflammatory drugs are not stimulating IL-1 production but are, in fact, relieving inhibition of the thymocyte IL-1 assay caused by the presence of prostaglandins.
Negative_regulation (inhibition) of IL-1 in thymocyte associated with inflammation and cinod
11) Confidence 0.41 Published 1988 Journal Cell. Immunol. Section Abstract Doc Link 2968844 Disease Relevance 0.10 Pain Relevance 0.10
As proof of concept that IL-1 inhibition may be clinically effective, we performed an open-label study of anakinra treatment in patients with acute gout.
Negative_regulation (inhibition) of IL-1 associated with anakinra and crystal associated disease
12) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.51 Pain Relevance 0.17
Based on these findings, we questioned whether IL-1 inhibition may also have a beneficial effect in gouty inflammation.
Negative_regulation (inhibition) of IL-1 associated with inflammation
13) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.87 Pain Relevance 0.17
The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested that IL-1 inhibition might also be effective in relieving the inflammatory manifestations of acute gout.
Negative_regulation (inhibition) of IL-1 associated with inflammation, syndrome and crystal associated disease
14) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906806 Disease Relevance 0.83 Pain Relevance 0.18
Interleukin-1 (IL-1) is an apical mediator in signalling cascades and has previously been shown to be important in response to vascular injury in mice6 and pigs.7 In the latter study, an inhibitor of IL-1 administered using osmotic pumps reduced in-stent restenosis after 28 and 90 days.
Negative_regulation (inhibitor) of IL-1 associated with cardiovascular disease and vasculitis
15) Confidence 0.39 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2791052 Disease Relevance 0.56 Pain Relevance 0
Neutrophils have been implicated in mediating this effect based on a study in rats where administration of anti-CINC-1 (CXCL1) neutralizing antibodies attenuated neutrophil recruitment and BBB breakdown downstream of intracerebral IL-1?
Negative_regulation (downstream) of IL-1 in neutrophil
16) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.17 Pain Relevance 0.10
Consistently with the stimulation of microglial cell priming by HS oligosaccharides in the brain, deletion of the innate immune response mediators TLR4 or MyD88 in MPSIIIB mice showed substantial reduction of CD11b staining and of the expression level of IL1?
Negative_regulation (level) of IL1 in microglial cell
17) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.39 Pain Relevance 0.04
A pilot study of IL-1 inhibition by anakinra in acute gout

Monosodium urate crystals stimulate monocytes and macrophages to release IL-1?

Negative_regulation (inhibition) of IL-1 in monocytes associated with anakinra and crystal associated disease
18) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1906806 Disease Relevance 0.88 Pain Relevance 0.23
IL-1 inhibition may be a promising therapeutic target in crystal-induced arthritis.


Negative_regulation (inhibition) of IL-1 associated with arthritis
19) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 1.46 Pain Relevance 0.39
Although these findings are positive, we have to stress that this was an open-label study and confirmation of these results would require a randomized controlled trial to prove that IL-1 inhibition is effective in acute gout.
Negative_regulation (inhibition) of IL-1 associated with stress and crystal associated disease
20) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 1.36 Pain Relevance 0.39

General Comments

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