INT178861

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAX, BCL2) endoplasmic reticulum (BAX, BCL2) cytoplasm (BAX, BCL2)
cytosol (BAX, BCL2) nucleus (BAX, BCL2) cell morphogenesis (BCL2)
BAX (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 41.68 Quite Low
Pain 1 6.64 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Antiemetics 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 137 100.00 Very High Very High Very High
Cancer 121 97.88 Very High Very High Very High
Breast Cancer 32 73.80 Quite High
Necrosis 5 55.96 Quite High
Toxicity 24 51.16 Quite High
Parkinson's Disease 1 50.40 Quite High
Death 24 36.00 Quite Low
Lymphatic System Cancer 2 18.56 Low Low
Adverse Drug Reaction 1 14.60 Low Low
Infection 1 13.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nbk interacts with Bcl-xL and Bcl-2 but not with Bax.
Bax Binding (with) of Bcl-2
1) Confidence 0.27 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.65 Pain Relevance 0
Bcl-2 is anti-apoptotic in function, whereas bax is proapoptotic and it is the interaction between the two that determines the likelihood of a tumor to undergo cytotoxic drug mediated regression.
bax Binding (interaction) of Bcl-2 associated with cancer and apoptosis
2) Confidence 0.20 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.55 Pain Relevance 0
Since Bax has the ability to heterodimerize with the Bcl-2 protein, the ratio of Bcl-2 to Bax appears to be an important marker for the occurrence of apoptosis [22].
Bax Binding (heterodimerize) of Bcl-2 associated with apoptosis
3) Confidence 0.11 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.87 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox