INT178889

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2011
Negated 0
Speculated 4
Reported most in Body
Documents 38
Total Number 46
Disease Relevance 36.69
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CHDH)
Anatomy Link Frequency
leaflets 3
CHDH (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 187 99.74 Very High Very High Very High
beta blocker 141 99.10 Very High Very High Very High
Angina 111 98.08 Very High Very High Very High
Calcium channel 18 89.76 High High
cva 183 89.20 High High
Percutaneous transluminal coronary angioplasty 42 84.12 Quite High
Bile 240 80.88 Quite High
depression 32 72.80 Quite High
Bioavailability 30 57.28 Quite High
Pain 36 40.96 Quite Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 2375 100.00 Very High Very High Very High
Coronary Heart Disease 231 100.00 Very High Very High Very High
Cv Unclassified Under Development 148 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 2312 99.94 Very High Very High Very High
Acute Coronary Syndrome 57 99.44 Very High Very High Very High
Death 218 99.20 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

225 98.98 Very High Very High Very High
Stroke 64 98.84 Very High Very High Very High
Cv General 3 Under Development 236 98.08 Very High Very High Very High
Obesity 61 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One pilot study investigated secondary prevention of CHD using a 'modular' approach [12].
Spec (investigated) Negative_regulation (prevention) of CHD associated with coronary artery disease
1) Confidence 0.48 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1590021 Disease Relevance 0.58 Pain Relevance 0.03
The results allow a clearer assessment of the duration and depth of the potential missed opportunities for CHD event prevention.
Negative_regulation (prevention) of CHD associated with coronary artery disease
2) Confidence 0.37 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1853095 Disease Relevance 0.54 Pain Relevance 0
Given this information, we would continue to recommend a healthy diet and exercise, but might decide that cholesterol-lowering medication is unnecessary [1], and that the benefits of aspirin in terms of CHD prevention do not outweigh the risk of hemorrhagic stroke associated with aspirin use [2].
Negative_regulation (prevention) of CHD associated with aspirin, coronary artery disease and stroke
3) Confidence 0.36 Published 2004 Journal BMC Med Section Body Doc Link PMC515311 Disease Relevance 0.61 Pain Relevance 0.18
Our approach takes into account the pre-test coronary risk, the expected distribution of CAC scores adjusted for all conventional CHD risk factors, and summary adjusted relative risks from a recent meta-analysis, and provides clinically relevant post-test risk estimates that may be directly useful to primary care physicians, cardiologists and patients as they decide whether or not to take medications for primary prevention of CHD.
Spec (whether) Negative_regulation (prevention) of CHD associated with coronary artery disease
4) Confidence 0.36 Published 2004 Journal BMC Med Section Body Doc Link PMC515311 Disease Relevance 0.97 Pain Relevance 0
The objectives of this study were to develop and evaluate a series of cardiac risk factor modules and corresponding information leaflets for secondary prevention of CHD.


Negative_regulation (prevention) of CHD in leaflets associated with coronary artery disease
5) Confidence 0.35 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1590021 Disease Relevance 0.42 Pain Relevance 0
The objective of this study was to develop and test a series of risk factor modules and corresponding patient information leaflets for secondary prevention of CHD.


Negative_regulation (prevention) of CHD in leaflets associated with coronary artery disease
6) Confidence 0.35 Published 2006 Journal BMC Health Serv Res Section Abstract Doc Link PMC1590021 Disease Relevance 0.41 Pain Relevance 0
Secondary prevention of CHD involves risk factor reduction through control of health behaviors such as diet, physical activity, smoking and medication adherence using a coordinated approach and referrals to health professionals [2,3].
Negative_regulation (prevention) of CHD associated with nicotine addiction and coronary artery disease
7) Confidence 0.35 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1590021 Disease Relevance 0.87 Pain Relevance 0.04
The leaflets are now considered suitable for use in further studies to test the effectiveness of a modular approach to secondary prevention of CHD and are expected to contribute to shared-decision making, patient empowerment and active patient participation.


Negative_regulation (prevention) of CHD in leaflets associated with coronary artery disease
8) Confidence 0.35 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1590021 Disease Relevance 0.32 Pain Relevance 0
We present the rationale and design of a multi-centre, replication study testing a modular approach for the secondary prevention of CHD following an ACS.


Negative_regulation (prevention) of CHD associated with acute coronary syndrome and coronary artery disease
9) Confidence 0.35 Published 2008 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC2572037 Disease Relevance 0.48 Pain Relevance 0
In aggregate, these studies suggest that giving patients global risk information in combination with individualized counseling and/or detailed group education (but not alone) may result in reductions in CHD risk factors (e.g. poor diet, physical inactivity, obesity, and smoking) and CHD risk.
Negative_regulation (reductions) of CHD associated with nicotine addiction, coronary artery disease and obesity
10) Confidence 0.34 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2294118 Disease Relevance 0.63 Pain Relevance 0
Analysis of major randomized control trials shows that each 1% increase in HDL-C is associated with a 0.7% to 3% decrease in CHD.19–21,27,28 Thus, the risk factor associated with low HDL-C should be considered as an major independent risk factor for CHD.29
Negative_regulation (decrease) of CHD associated with coronary artery disease and disorder of lipid metabolism
11) Confidence 0.32 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.47 Pain Relevance 0
The investigators proposed that the decreases in TC and LDL-C accounted for the majority of the benefit, while the small increase in HDL-C (about 3%) accounted for a 2% decrease in CHD.


Negative_regulation (decrease) of CHD associated with coronary artery disease and disorder of lipid metabolism
12) Confidence 0.32 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.45 Pain Relevance 0
For the most part, lipid panel changes were responsible for the decrease in CHD.
Negative_regulation (decrease) of CHD associated with coronary artery disease
13) Confidence 0.32 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.59 Pain Relevance 0
Thus, a 1% increase in HDL-C can bring about a 2% to 3% decrease in CHD.
Negative_regulation (decrease) of CHD associated with coronary artery disease and disorder of lipid metabolism
14) Confidence 0.32 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.44 Pain Relevance 0
In addition, increases in HDL-C are associated with better CHD outcomes, and the level of HDL-C is an independent predictor of CHD.24 The evidence that increasing HDL-C decreases CHD is moderately strong Grade A/B evidence from randomized controlled trials and meta-analyses, and supports consideration of targeting HDL-C, particularly in subjects with low levels, as well as LDL-C reduction.
Negative_regulation (decreases) of CHD associated with coronary artery disease and disorder of lipid metabolism
15) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.97 Pain Relevance 0
Other recent evidence has been found supporting the Mediterranean diet's protective effect in the secondary prevention of CHD [50–52].
Negative_regulation (prevention) of CHD associated with coronary heart disease
16) Confidence 0.27 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3010651 Disease Relevance 0.70 Pain Relevance 0
However, as appropriate therapy is a key aspect of secondary prevention of CHD [8], this should surely be given greater consideration.
Negative_regulation (prevention) of CHD associated with coronary heart disease
17) Confidence 0.27 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3010651 Disease Relevance 0.34 Pain Relevance 0
Not only is the time and cost necessary for this measure prohibitive, but previous research has clearly established link between reductions in CHD risk factors and CHD events [45,46].
Negative_regulation (reductions) of CHD associated with coronary artery disease
18) Confidence 0.25 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2294118 Disease Relevance 0.56 Pain Relevance 0
All patients who had a CHD risk calculated were counseled on ways to reduce CHD risk, and they were offered follow-up at a frequency commensurate with their level of risk (i.e. more frequent follow-up for higher risk patients).
Negative_regulation (reduce) of CHD associated with coronary artery disease
19) Confidence 0.25 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2294118 Disease Relevance 0.68 Pain Relevance 0
In our search for articles about the potential harms associated with physician knowledge of global CHD risk scores, we excluded articles because (1) they were unrelated to the harms of CHD risk disclosure; (2) they were related to CHD risk disclosure, but were not about disclosing global CHD risk; (3) they answered the wrong question (e.g. the effects of disclosure in secondary prevention); or (4) they didn't have an experimental design.


Negative_regulation (disclosing) of CHD associated with coronary artery disease
20) Confidence 0.25 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2294118 Disease Relevance 0.84 Pain Relevance 0

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