INT178909

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 2.09
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
hepatocytes 4
liver 1
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 368 99.08 Very High Very High Very High
agonist 23 87.12 High High
medulla 28 86.20 High High
narcan 14 70.16 Quite High
Opioid 64 65.76 Quite High
anesthesia 10 49.56 Quite Low
antagonist 19 29.96 Quite Low
dexamethasone 12 5.00 Very Low Very Low Very Low
Action potential 12 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 212 99.64 Very High Very High Very High
Fistula 114 98.88 Very High Very High Very High
Bordatella Infection 20 92.80 High High
Targeted Disruption 15 56.88 Quite High
Toxicity 8 54.08 Quite High
Repression 24 5.00 Very Low Very Low Very Low
Van Bogaert's Disease 18 5.00 Very Low Very Low Very Low
Biliary Fistula 6 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 6 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the preliminary experiments, tetrandrine was found to significantly modify mRNA and protein levels of glucose transporters subtype 4 (GLUT4) and hepatic phosphoenolpyruvate carboxykinase (PEPCK) in STZ-diabetic rats after a 3-day treatment.
Transcription (levels) of PEPCK associated with diabetes mellitus
1) Confidence 0.56 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.26 Pain Relevance 0.04
The mRNA levels of glucose transporter subtype 4 (GLUT4) in soleus muscle and phosphoenolpyruvate carboxykinase (PEPCK) in the liver of STZ-diabetic rats were detected by Northern blotting analysis.
Transcription (levels) of PEPCK in liver associated with diabetes mellitus
2) Confidence 0.54 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC516459 Disease Relevance 0.55 Pain Relevance 0.16
PTX alone does not affect PEPCK or G6Pase mRNA levels.
Transcription (levels) of PEPCK
3) Confidence 0.47 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.07 Pain Relevance 0.10
The addition of TCA alone to primary rat hepatocytes in culture rapidly (1–2 h) downregulated both PEPCK (Fig. 3A) and G-6-Pase mRNA levels (Fig. 3B).
Transcription (levels) of PEPCK in hepatocytes
4) Confidence 0.45 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.20 Pain Relevance 0.21
50%, 30 min) downregulated mRNA levels of PEPCK and G-6-Pase (Fig. 2).
Transcription (levels) of PEPCK
5) Confidence 0.45 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.24 Pain Relevance 0.27
Downregulation of PEPCK and G-6-Pase mRNA by TCA in the chronic bile fistula rat and primary rat hepatocytes
Transcription (mRNA) of PEPCK in hepatocytes associated with bile and fistula
6) Confidence 0.45 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.32
50%, 1–2 h) downregulated PEPCK and G-6-Pase mRNA levels in PRH.
Transcription (levels) of PEPCK in PRH
7) Confidence 0.45 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.34 Pain Relevance 0.11
As expected, the addition of insulin alone to primary rat hepatocytes rapidly downregulated PEPCK and G-6-Pase mRNA levels.
Transcription (levels) of PEPCK in hepatocytes
8) Confidence 0.35 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.19 Pain Relevance 0.19
Genetic dissection of the GTP response in Paramecium
Transcription (dissection) of GTP
9) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0

General Comments

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