INT17892

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 57
Total Number 58
Disease Relevance 36.37
Pain Relevance 5.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
keratinocytes 6
skin 3
endometrium 2
SNU-1 2
colon 2
Myc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 28 99.84 Very High Very High Very High
Nerve growth factor 1 99.68 Very High Very High Very High
cINOD 32 99.60 Very High Very High Very High
endometriosis 234 98.56 Very High Very High Very High
rheumatoid arthritis 71 98.56 Very High Very High Very High
cytokine 48 98.16 Very High Very High Very High
Glutamate 52 97.48 Very High Very High Very High
Eae 6 95.84 Very High Very High Very High
Dorsal horn 1 94.96 High High
GABAergic 26 93.68 High High
Disease Link Frequency Relevance Heat
Apoptosis 732 100.00 Very High Very High Very High
Cancer 597 100.00 Very High Very High Very High
Repression 46 100.00 Very High Very High Very High
Metastasis 48 99.88 Very High Very High Very High
Bullous Skin Disease 3344 99.60 Very High Very High Very High
Ovarian Cancer 84 99.44 Very High Very High Very High
Acantholysis 715 98.84 Very High Very High Very High
Stomach Cancer 8 98.76 Very High Very High Very High
Brain Injury 125 98.72 Very High Very High Very High
Endometriosis 240 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane.
Gene_expression (expression) of c-myc in colon
1) Confidence 0.75 Published 2002 Journal J. Gastroenterol. Section Title Doc Link 11931531 Disease Relevance 0.28 Pain Relevance 0.37
Moreover, following obstruction of the bladders of animal models and patients with BPH, there were acute increases in the expression of bFGF (7), the transcription factors, upstream binding factor, c-Jun, and cyclins E and C (8), nerve growth factor (9), N-ras and c-myc (10), and decreased expression of TGF-beta 1 (7).
Gene_expression (expression) of c-myc in nerve associated with benign prostatic hypertrophy and nerve growth factor
2) Confidence 0.75 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.60 Pain Relevance 0.08
Depsipeptide has been shown to induce differentiation, cause G1 and G2/M cell cycle arrest and apoptosis, increase expression of p21 and cyclin E, decrease expression of cyclin D1 and c-myc, and cause hypophosphorylation of Rb (Sandor et al 2000; Picardo et al 2004; Piekarz et al 2004; Piekarz and Bates 2004).
Gene_expression (expression) of c-myc in M cell associated with apoptosis
3) Confidence 0.75 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 0.63 Pain Relevance 0
As outlined above, PV-IgG-induced plakoglobin depletion resulted in c-Myc overexpression in cultured keratinocytes (Muller et al. 2008a; Williamson et al. 2006).
Gene_expression (overexpression) of c-Myc in keratinocytes associated with bullous skin disease
4) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.14 Pain Relevance 0.06
Expression of c-Myc and TGF?
Gene_expression (Expression) of c-Myc
5) Confidence 0.75 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 1.60 Pain Relevance 0
Moreover, altered plakoglobin signalling leading to c-Myc overexpression was found in PV patients’s skin but not in PF (Williamson et al. 2007, 2006).
Gene_expression (overexpression) of c-Myc in skin associated with bullous skin disease
6) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 2.20 Pain Relevance 0.11
Accordingly, c-Myc overexpression was found in the epidermis of PV patients, but interestingly not in PF skin, indicating that this mechanism may only be important for PV (Williamson et al. 2007, 2006).
Gene_expression (overexpression) of c-Myc in skin associated with bullous skin disease
7) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.17 Pain Relevance 0.06
Furthermore, these mice had a 24-hr lag in the hepatic expression of the G1/S checkpoint regulator genes cyclin D1 (Ccnd1) and c-myc and increased expression of the interleukin-1?
Gene_expression (expression) of c-myc
8) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.92 Pain Relevance 0.14
However, the findings that c-Myc overexpression was found after 24 h, whereas PV-IgG-induced loss of cell aggregation was observed as early as after 12 h and that c-Myc overexpression was absent in PF skin indicate that c-Myc overexpression likely contributes to ongoing proliferation of keratinocytes in PV, whereas it seems not to be essential for acantholysis.
Neg (absent) Gene_expression (overexpression) of c-Myc in keratinocytes associated with acantholysis and bullous skin disease
9) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.30 Pain Relevance 0
In the epidermis, Rac 1 was found not to be crucial for maintaining epithelial integrity but for stem cell differentiation, presumably via negative regulation of c-Myc expression (Benitah et al. 2005; Chrostek et al. 2006).
Gene_expression (expression) of c-Myc in epidermis
10) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.65 Pain Relevance 0
-catenin followed by translocation to the nucleus and regulation of cyclin D1 expression and c-myc [204].
Gene_expression (expression) of c-myc in nucleus
11) Confidence 0.75 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.78 Pain Relevance 0.13
In our study, de- ATSC overexpressed not only Oct-4, Sox-2, Nanog, and Rex-1, but also c-Myc for the acquisition of active self-renewal activity with pluripotency.
Gene_expression (overexpressed) of c-Myc
12) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.23 Pain Relevance 0
However, the findings that c-Myc overexpression was found after 24 h, whereas PV-IgG-induced loss of cell aggregation was observed as early as after 12 h and that c-Myc overexpression was absent in PF skin indicate that c-Myc overexpression likely contributes to ongoing proliferation of keratinocytes in PV, whereas it seems not to be essential for acantholysis.
Gene_expression (overexpression) of c-Myc in keratinocytes associated with acantholysis and bullous skin disease
13) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.28 Pain Relevance 0
However, the expression of other genes such as epidermal growth factor-receptor, glial fibrillary acidic protein, and several proto-oncogenes (src, fos and myc), and a cholinergic marker such as choline acetyltransferase activity were unaltered.
Gene_expression (expression) of myc
14) Confidence 0.75 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7854069 Disease Relevance 0 Pain Relevance 0.20
Consequently, SNU-1 cells are sensitive to CAP in the overexpression of tumor suppressor gene, p53 and proto-oncogenes, c-myc and c-Ha-ras, but not those of c-erbB-2, c-jun and bcl-2 genes.
Gene_expression (overexpression) of c-myc in SNU-1 associated with qutenza and cancer
15) Confidence 0.75 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.18 Pain Relevance 1.01
Our results suggest that CAP induces apoptotic cell death in human gastric cancer cells (SNU-1) in vitro which may be possibly mediated by the overexpression of p53 and/or c-myc genes.
Gene_expression (overexpression) of c-myc in SNU-1 associated with qutenza, apoptosis, stomach cancer and death
16) Confidence 0.75 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.10 Pain Relevance 0.79
The aim of this study was to examine the effects of NSAIDs on the expression of the tumor suppressor APC gene and the c-myc oncogene in the colons of rats treated with a colon-specific carcinogen, azoxymethane (AOM).
Gene_expression (expression) of c-myc in colon associated with cancer and cinod
17) Confidence 0.75 Published 2002 Journal J. Gastroenterol. Section Abstract Doc Link 11931531 Disease Relevance 0.28 Pain Relevance 0.38
In addition, c-myc mRNA expression was clearly decreased in the group of rats treated with both AOM and NS-398 compared with the level in the group of rats treated with AOM alone.
Gene_expression (expression) of c-myc
18) Confidence 0.75 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our data thus indicate that NS-398 causes an increase in APC expression and a decrease in c-myc expression.


Gene_expression (expression) of c-myc
19) Confidence 0.75 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
The altered expression of c-myc, TGF-?
Gene_expression (expression) of c-myc
20) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 1.46 Pain Relevance 0.21

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