INT178927

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
bone marrow 2
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 14 50.00 Quite Low
Inflammation 49 29.68 Quite Low
cytokine 28 26.24 Quite Low
Kinase C 12 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 188 100.00 Very High Very High Very High
Apoptosis 102 99.64 Very High Very High Very High
Death 57 98.40 Very High Very High Very High
Leukemia 4 94.56 High High
Genomic Instability 13 89.40 High High
Chromosome Aberrations 2 86.20 High High
Infection 12 76.24 Quite High
Toxicity 6 70.40 Quite High
Shock 1 57.20 Quite High
Necrosis 7 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro cell proliferation analyses was done to evaluate the effect of adenovirus-mediated wild-type p53 expression.
Regulation (effect) of Gene_expression (expression) of p53
1) Confidence 0.26 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.67 Pain Relevance 0
In vitro study of cell growth using cell proliferation analyses was done to evaluate the effect of adenovirus-mediated wild-type p53 expression.
Regulation (effect) of Gene_expression (expression) of p53
2) Confidence 0.26 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.22 Pain Relevance 0
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Regulation (through) of Gene_expression (expression) of p53 associated with cancer, apoptosis and death
3) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.60 Pain Relevance 0
In contrast, lowering p53 levels by siRNA did not influence the decrease in cell proliferation caused by IFN?
Neg (not) Regulation (influence) of Gene_expression (levels) of p53
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.18 Pain Relevance 0
did not influence cyclinD1 nor p53 levels, as shown by immunoblotting (Fig. 3C).
Neg (nor) Regulation (influence) of Gene_expression (levels) of p53
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.08 Pain Relevance 0
Niacin deficiency significantly delayed DNA repair in bone marrow after ENU- or ETO-treatment [103, 105] and was shown to alter p53 expression and impair ETO-induced cell cycle arrest and apoptosis [104].


Regulation (alter) of Gene_expression (expression) of p53 in bone marrow associated with apoptosis
6) Confidence 0.04 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.47 Pain Relevance 0

General Comments

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