INT17893

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.28
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
keratinocyte 1
hearts 1
Myc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 9 56.16 Quite High
cytokine 11 55.12 Quite High
anesthesia 2 37.36 Quite Low
Thoracotomy 1 30.32 Quite Low
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 4 99.44 Very High Very High Very High
Acantholysis 65 98.56 Very High Very High Very High
Bullous Skin Disease 304 97.92 Very High Very High Very High
Adhesions 55 93.92 High High
Breast Cancer 3 93.64 High High
Carcinoma 3 80.40 Quite High
Infection 76 77.76 Quite High
Stress 5 76.24 Quite High
Cancer 27 75.44 Quite High
Lymphatic System Cancer 4 74.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An early, transient accumulation of mRNAs of the protooncogenes c-fos and c-myc and the heat-shock protein HSP70 has been described in hypertrophying rat hearts.
Positive_regulation (accumulation) of c-myc in hearts associated with shock
1) Confidence 0.67 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1951731 Disease Relevance 0.25 Pain Relevance 0
B–mediated upregulation of c-Myc, cyclins, and CDK4 [7,10,11].
Positive_regulation (upregulation) of c-Myc
2) Confidence 0.67 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.63 Pain Relevance 0.06
However, at present, it is unclear how continuing keratinocyte proliferation in consequence to increased c-Myc and cdk2 signalling contributes to acantholysis in PV.
Positive_regulation (increased) of c-Myc in keratinocyte associated with acantholysis and bullous skin disease
3) Confidence 0.67 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.48 Pain Relevance 0
EpCAM has a direct impact on cell cycle and proliferation, and the ability to upregulate the proto-oncogene, c-myc, and cyclin A/E rapidly.
Positive_regulation (upregulate) of c-myc
4) Confidence 0.45 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004584 Disease Relevance 0.92 Pain Relevance 0

General Comments

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