INT17894

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.65
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
spinal cord 1
colon 1
T cell 1
Myc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 9 100.00 Very High Very High Very High
Thoracotomy 1 98.08 Very High Very High Very High
Spinal cord 31 95.08 Very High Very High Very High
anesthesia 8 94.52 High High
Opioid 1 83.08 Quite High
Inflammation 16 82.88 Quite High
Cholecystokinin 1 80.48 Quite High
gABA 2 78.56 Quite High
Dopamine 3 78.32 Quite High
ischemia 1 58.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 195 100.00 Very High Very High Very High
Stress 14 100.00 Very High Very High Very High
Stomach Cancer 1 99.32 Very High Very High Very High
Cv Unclassified Under Development 2 99.00 Very High Very High Very High
Prolactinoma 18 98.50 Very High Very High Very High
Injury 70 96.44 Very High Very High Very High
Repression 5 96.44 Very High Very High Very High
Apoptosis 142 95.68 Very High Very High Very High
Colon Cancer 64 94.60 High High
Neurodegenerative Disease 36 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, cell cycle genes, including Wee-1, c-myc, and Cyclin-D1, are regulated in a circadian manner [77], further suggesting that the regular timing of these genes contributes to normal cell functioning.
Regulation (regulated) of c-myc
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995744 Disease Relevance 0.62 Pain Relevance 0
The coronary c-Fos and c-Myc labeling remained unchanged in these conditions.
Neg (unchanged) Regulation (unchanged) of c-Myc
2) Confidence 0.44 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1951731 Disease Relevance 0.31 Pain Relevance 0.14
For example, there is the down-regulation of cyclin D1, cyclin-dependent kinase 4, c-myc and Bcl-2 [19, 24].
Regulation (regulation) of c-myc
3) Confidence 0.44 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.09 Pain Relevance 0
The aim of this study was to examine the effects of NSAIDs on the expression of the tumor suppressor APC gene and the c-myc oncogene in the colons of rats treated with a colon-specific carcinogen, azoxymethane (AOM).
Regulation (effects) of c-myc in colon associated with cancer and cinod
4) Confidence 0.44 Published 2002 Journal J. Gastroenterol. Section Abstract Doc Link 11931531 Disease Relevance 0.29 Pain Relevance 0.38
In E(2)-induced rat prolactinomas, prolactin mRNA contents and the expression of some proto-oncogenes, e.g. c-myc and c-ras, TGFalpha and TGFbeta1 mRNA were significantly changed.
Regulation (changed) of c-myc associated with prolactinoma
5) Confidence 0.44 Published 2000 Journal Biol Signals Recept Section Abstract Doc Link 10686432 Disease Relevance 0.87 Pain Relevance 0.20
-catenin/T cell factor-4 tumor suppressor pathway, which is involved in the regulation of growth promoting genes such as c-myc and cyclin D1.
Regulation (regulation) of c-myc in T cell associated with cancer
6) Confidence 0.26 Published 2003 Journal Comp Hepatol Section Abstract Doc Link PMC151270 Disease Relevance 0.65 Pain Relevance 0.03
In contrast, we have not observed modulation of c-myc, MCL-1 or cIAP1 or cIAP2 in our system, using HCT116 cells which are bax proficient.
Regulation (modulation) of c-myc
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.75 Pain Relevance 0.04
Up-regulation of stress response (MAFK, IKBZ, SOCS3) and early growth response (c-Myc, c-Jun, c-Fos, DUSP1 and 6) genes as assessed by RT-qPCR and/or microarray profiling was unchanged.
Regulation (regulation) of c-Myc associated with stress
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.19 Pain Relevance 0
A recent work also demonstrated that c-Myc is a target of lapatinib in gastric cancer cell lines [25].
Regulation (target) of c-Myc associated with stomach cancer
9) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.52 Pain Relevance 0
MYC, a member of the myc-family of transcription factors, is a complex regulator of general transcriptional activation [50] and has been associated with immediate early injury response of neurons in the spinal cord [51].
Regulation (regulator) of MYC in spinal cord associated with injury and spinal cord
10) Confidence 0.24 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.36 Pain Relevance 0.13

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