INT178962

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 5.15
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Oca2) cell proliferation (Oca2) transport (Oca2)
transmembrane transport (Oca2)
Anatomy Link Frequency
macrophages 1
granulocytes 1
bone marrow 1
uterine 1
Oca2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 124 99.98 Very High Very High Very High
ischemia 64 56.16 Quite High
Eae 2 54.96 Quite High
Pain 6 50.40 Quite High
Dismenorea 6 47.28 Quite Low
Central nervous system 4 36.24 Quite Low
Piles 4 32.20 Quite Low
metalloproteinase 9 19.56 Low Low
tolerance 26 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 119 100.00 Very High Very High Very High
Ovarian Cancer 16 100.00 Very High Very High Very High
Thyroid Neoplasm 6 100.00 Very High Very High Very High
Lung Cancer 4 100.00 Very High Very High Very High
Esophageal Cancer 2 100.00 Very High Very High Very High
Testicular Cancer 1 100.00 Very High Very High Very High
Breast Cancer 5 99.52 Very High Very High Very High
Bacterial Respiratory Disease 4 99.12 Very High Very High Very High
Uterine Fibroids 1 98.28 Very High Very High Very High
Liver Cancer 3 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another limitation of this study was that the outcomes were not only for P-IVS but also for the surgeries conducted in conjunction with P-IVS.
Gene_expression (for) of P-IVS
1) Confidence 0.19 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855447 Disease Relevance 0.22 Pain Relevance 0.05
Regardless of how success is defined, the literature consistently shows an excellent success rate, suggesting that the P-IVS procedure is an effective treatment for restoration of the apical defect.
Gene_expression (procedure) of P-IVS
2) Confidence 0.16 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855447 Disease Relevance 0.60 Pain Relevance 0.03
The molecular weight of the GFP protein is 29.0 Kda and the molecular weight of bacterial expressed P protein is 32.5 Kda [27].
Gene_expression (expressed) of P protein
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0 Pain Relevance 0
Fluorescent microscopy and Western blotting confirmed expression of P protein fused with GFP.
Gene_expression (expression) of P protein
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0 Pain Relevance 0
Transfected cells were observed under florescent microscope periodically to check the expression of green fluorescent protein (GFP) fused CHPV P protein and confirmed by western blotting using anti-GFP antibodies (Invitrogen, Carlsbad, CA, USA).


Gene_expression (expression) of P protein
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0.24 Pain Relevance 0
expression levels in pMCAO and sham-operated mice.
Gene_expression (expression) of pMCAO
6) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.05 Pain Relevance 0.11
Two populations of CD11b+CD45high cells were visible on flow cytometric dot plots from mice exposed to 24 hours of pMCAO, which differed by expressing intermediate or high levels of CD11b (Figure 4C).
Gene_expression (expressing) of pMCAO
7) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0
Similarly, we found no evidence of altered CD45 expression when comparing stainings with a generally expressed CD45 marker in chimeric and non-chimeric mice 24 hours after pMCAO (Figure 2N, P).
Gene_expression (expression) of pMCAO
8) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0
-expressing microglia by far exceeded the number of cytokine-expressing macrophages 12 hours after pMCAO.
Gene_expression (expressing) of pMCAO in macrophages associated with cytokine
9) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0.05
expressing CD45highGr1+ granulocytes at 24 hours after pMCAO compared to unmanipulated control mice.
Gene_expression (expressing) of pMCAO in granulocytes
10) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.06 Pain Relevance 0.10
Blood-borne, bone marrow-derived cells infiltrate after pMCAO
Gene_expression (infiltrate) of pMCAO in bone marrow
11) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0
expression by CD11b+CD45high cells after 24 hours of pMCAO, indicating that the contribution of these cells to the production of IL-1?
Gene_expression (expression) of pMCAO
12) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.16 Pain Relevance 0
protein-expressing cells in SJL and C57BL/6 mice, 12–24 hours after pMCAO [12,14,25].
Gene_expression (expressing) of pMCAO
13) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.14 Pain Relevance 0.04
Later, the overexpression of this gene was reported in many other tumors including esophageal cancer [63], thyroid cancer [55], small cell lung cancer and non-small cell lung cancer [18,64,65], testicular cancer [15,66], OCA [6,15,67], breast cancer [14,59], uterine leiomyomas [16], liver cancer [68], and colorectal cancer [69].
Gene_expression (overexpression) of OCA in uterine associated with uterine fibroids, lung cancer, colon cancer, breast cancer, ovarian cancer, esophageal cancer, liver cancer, thyroid neoplasm, cancer and testicular cancer
14) Confidence 0.02 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 2.21 Pain Relevance 0
The 4211(4212) Da protein has not yet been identified, but only two candidate groups of vertebrate proteins are found by scanning Swiss-Prot database (molecular weight, 4211; molecular weight ranges, 0.1% according to the standard errors of the current MS analysis; pI, 6; pI ranges, 10): pancreatic polypeptide (PP) (primary accession numbers P13083, P37999, P41519, P38000, P11967) and antibacterial peptides [?
Gene_expression (primary) of P37999 associated with bacterial respiratory disease
15) Confidence 0.00 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.66 Pain Relevance 0
The 4211(4212) Da protein has not yet been identified, but only two candidate groups of vertebrate proteins are found by scanning Swiss-Prot database (molecular weight, 4211; molecular weight ranges, 0.1% according to the standard errors of the current MS analysis; pI, 6; pI ranges, 10): pancreatic polypeptide (PP) (primary accession numbers P13083, P37999, P41519, P38000, P11967) and antibacterial peptides [?
Gene_expression (primary) of P41519 associated with bacterial respiratory disease
16) Confidence 0.00 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.66 Pain Relevance 0

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