INT178986

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.58
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMP9, TIMP1) peptidase activity (MMP9) extracellular space (MMP9)
aging (TIMP1) proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9)
Anatomy Link Frequency
medial 1
ciliated cells 1
MMP9 (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 115 100.00 Very High Very High Very High
long-term potentiation 4 96.48 Very High Very High Very High
Inflammation 19 95.98 Very High Very High Very High
Hippocampus 1 91.76 High High
Central nervous system 2 83.24 Quite High
cytokine 17 67.28 Quite High
depression 35 52.04 Quite High
Inflammatory mediators 1 38.72 Quite Low
Dysuria 2 18.16 Low Low
chemokine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 36 99.16 Very High Very High Very High
INFLAMMATION 23 95.98 Very High Very High Very High
Renal Cancer 8 94.72 High High
Transitional Cell Carcinoma 52 94.16 High High
Cancer 73 87.28 High High
Bladder Cancer 58 85.48 High High
Dementia 1 84.96 Quite High
Aggression 4 84.16 Quite High
Disease 43 81.72 Quite High
Schizophrenia 50 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies have shown that TIMP1 binds preferably to MMP9 and TIMP2 to MMP2 [18,19].
MMP9 Binding (binds) of TIMP1
1) Confidence 0.47 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.67 Pain Relevance 0.51
Studies have shown that TIMP1 binds preferably to MMP9 and TIMP2 preferably to MMP2 [18].
MMP9 Binding (binds) of TIMP1
2) Confidence 0.35 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.81 Pain Relevance 0.19
TIMP-1, which binds to MMP-9 and regulate its activity, was indeed shown to be able to prevent MMP-9-dependent late LTP in the rat medial PFC [26].
MMP-9 Binding (binds) of TIMP-1 in medial associated with long-term potentiation
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820097 Disease Relevance 0.58 Pain Relevance 0.52
Acute irritation and inflammation of cilia due to exposure to tobacco smoke could explain this alteration; d) mucus seems to not be physiologically affected at this stage; and e) tobacco smoke triggers an increased activity of matrix metalloproteinases (in particular MMP9) associated with disruption of the extracellular matrix, most likely affecting cellular attachments to the basal membrane generating a substantial exfoliation of the ciliated cells.
MMP9 Binding (associated) of metalloproteinases in ciliated cells associated with nicotine addiction, inflammation and metalloproteinase
4) Confidence 0.02 Published 2004 Journal Respir Res Section Body Doc Link PMC517705 Disease Relevance 0.52 Pain Relevance 0.10

General Comments

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