INT178987

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.81
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
macrophage 2
chondrocytes 2
ciliated cells 2
epithelium 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 30 100.00 Very High Very High Very High
Osteoarthritis 39 99.60 Very High Very High Very High
chemokine 10 97.68 Very High Very High Very High
Inflammation 64 96.80 Very High Very High Very High
Arthritis 2 93.56 High High
cytokine 23 78.96 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 66 99.98 Very High Very High Very High
Breast Cancer 5 99.84 Very High Very High Very High
Osteoarthritis 51 99.60 Very High Very High Very High
Disease 10 97.08 Very High Very High Very High
INFLAMMATION 68 96.80 Very High Very High Very High
Arthritis 5 93.56 High High
Pancreatic Cancer 3 93.32 High High
Metastasis 1 85.52 High High
Cancer 17 74.84 Quite High
Injury 18 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M AA with increasing concentrations of EPA, DPA or DHA for 24 h did not diminish or increase the secretion of MMP-9 (Fig. 3).
Positive_regulation (increasing) of Positive_regulation (concentrations) of EPA
1) Confidence 0.20 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
In contrast, others have found that suppression of EP2 expression enhances MMP-13 collagenase induction in human OA chondrocytes [39].
Positive_regulation (enhances) of Positive_regulation (induction) of collagenase in chondrocytes associated with metalloproteinase and osteoarthritis
2) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.56 Pain Relevance 0.28
Tobacco smoke triggers an increased activity of matrix metalloproteinases associated with a substantial defoliation of ciliated epithelium.
Positive_regulation (triggers) of Positive_regulation (increased) of metalloproteinases in epithelium associated with nicotine addiction and metalloproteinase
3) Confidence 0.04 Published 2004 Journal Respir Res Section Abstract Doc Link PMC517705 Disease Relevance 0.58 Pain Relevance 0.05
Acute irritation and inflammation of cilia due to exposure to tobacco smoke could explain this alteration; d) mucus seems to not be physiologically affected at this stage; and e) tobacco smoke triggers an increased activity of matrix metalloproteinases (in particular MMP9) associated with disruption of the extracellular matrix, most likely affecting cellular attachments to the basal membrane generating a substantial exfoliation of the ciliated cells.
Positive_regulation (triggers) of Positive_regulation (increased) of metalloproteinases in ciliated cells associated with nicotine addiction, inflammation and metalloproteinase
4) Confidence 0.03 Published 2004 Journal Respir Res Section Body Doc Link PMC517705 Disease Relevance 0.53 Pain Relevance 0.10
Finally, MCP-1, a member of the CC chemokine family, possesses chemotactic activity for monocytes and T lymphocytes [34,35] and has been proposed to play a key role in macrophage recruitment, expression of angiogenic factors and activation of matrix metalloproteinases in breast cancer patients.
Positive_regulation (role) of Positive_regulation (activation) of metalloproteinases in macrophage associated with chemokine, breast cancer and metalloproteinase
5) Confidence 0.02 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2626602 Disease Relevance 1.14 Pain Relevance 0.40

General Comments

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