INT179023

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.53
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
dorsal horn 1
FL (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 10 99.68 Very High Very High Very High
medulla 2 98.52 Very High Very High Very High
Hyperalgesia 4 97.32 Very High Very High Very High
Pain 19 90.36 High High
qutenza 20 80.52 Quite High
Inflammation 23 79.28 Quite High
Hippocampus 2 72.44 Quite High
Spinal cord 1 59.72 Quite High
Dorsal horn 8 45.36 Quite Low
ischemia 22 40.56 Quite Low
Disease Link Frequency Relevance Heat
Follicular Lymphoma 22 100.00 Very High Very High Very High
B-cell Lymphoma 27 99.78 Very High Very High Very High
Hypersensitivity 28 98.28 Very High Very High Very High
Hyperalgesia 6 97.32 Very High Very High Very High
Nociception 26 93.88 High High
Lymphatic System Cancer 122 93.84 High High
Pain 23 90.36 High High
Hematologic Neoplasms 2 80.00 Quite High
INFLAMMATION 25 79.28 Quite High
Targeted Disruption 19 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noxious stimulation increases BDNF and trkB.FL production in the spinal dorsal horn [5-9] and brainstem [10,11], leading to hyperalgesia and the formation of nocifensive behaviors.
Gene_expression (production) of FL in dorsal horn associated with medulla, hyperalgesia and spinal dorsal horn
1) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.59 Pain Relevance 0.37
The expression of trkB.FL and trkB.T1 is conserved across species and throughout evolution, and trkB isoform expression is regulated during development when the dominant trkB isoform expression in the brain switches from trkB.FL to trkB.T1 [39].
Gene_expression (expression) of FL in brain
2) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.19
By using the primary antibody 6H4, which is directed against an epitope within the first alpha helix, full-length unglycosylated PrPC (PrPC FL) was detected at an apparent molecular weight of 28.5 kDa.
Gene_expression (detected) of FL
3) Confidence 0.26 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.05 Pain Relevance 0.04
Furthermore, the integral of the TM signal is presented, as well as the first derivative of the DL, FL and DP signals.
Gene_expression (presented) of FL
4) Confidence 0.05 Published 2004 Journal BMC Pulm Med Section Body Doc Link PMC517937 Disease Relevance 0 Pain Relevance 0
Although no specific phenotype was found for MZL, levels of CD19 expression in conjunction with CD11c and CD38 expression can distinguish MZL from CD10 negative FL [76].
Neg (negative) Gene_expression (negative) of FL associated with b-cell lymphoma and follicular lymphoma
5) Confidence 0.04 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 2.23 Pain Relevance 0.03

General Comments

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