INT179034

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.12
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Anatomy Link Frequency
retina 1
kidney 1
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 100.00 Very High Very High Very High
agonist 16 84.32 Quite High
antagonist 8 53.28 Quite High
fibrosis 6 29.20 Quite Low
Central nervous system 1 23.52 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Enkephalin 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 100.00 Very High Very High Very High
INFLAMMATION 14 100.00 Very High Very High Very High
Cancer 251 99.28 Very High Very High Very High
Carcinoma 35 95.64 Very High Very High Very High
Breast Cancer 56 93.04 High High
Hepatocellular Cancer 78 91.20 High High
Apoptosis 87 90.68 High High
Glioma 26 86.80 High High
Stomach Cancer 38 82.80 Quite High
Infection 24 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactivity for p27 was observed in the nuclei of most glomerular and tubular cells in the normal kidney. p27 immunostaining in CDC showed high variability.
p27 Binding (Immunoreactivity) of in kidney associated with carcinoma
1) Confidence 0.31 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.62 Pain Relevance 0
The following gene products emerged as hubs: Fos, a transcription factor involved in stress response; glucocorticoid receptor (encoded by Nr3c1), involved in stress response and inflammation; RhoA, an important signaling molecule associated with cytoskeletal remodeling; and Cdkn1b, which maintains cell cycle arrest.
Cdkn1b Binding (emerged) of associated with stress and inflammation
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.84 Pain Relevance 0.05
Cytoplasmic translocation of p27Kip1 has been increasingly recognized in primary human tumors associated with poor survival whereas nuclear expression confers a more favorable outcome [12].
p27Kip1 Binding (recognized) of associated with cancer
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 1.00 Pain Relevance 0
A member of KIP/CIP family of cyclin-dependent kinase inhibitors, p27 blocks G1-S cell cycle progression by binding and inhibiting cyclin-E/cyclin-dependent kinase-2 [45].
p27 Binding (binding) of
4) Confidence 0.12 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.94 Pain Relevance 0.07
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
p27 Binding (cyclinD1) of
5) Confidence 0.10 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.01 Pain Relevance 0
As p21WAF1 and p27 are cyclin-dependent kinase inhibitors that bind to cyclin-dependent kinase complexes and decrease kinase activity, they may act as key regulators of G0/G1 accumulation [30].
p27 Binding (bind) of
6) Confidence 0.07 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.57 Pain Relevance 0
In E7 retina, immunoreactivity for p27kip1 was seen in numerous nuclei scattered throughout the retina, but was absent from the nuclei of proliferating progenitors in distal layers of the retina (Figs. 2g–i).
p27kip1 Binding (immunoreactivity) of in retina
7) Confidence 0.02 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.14 Pain Relevance 0

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