INT179036
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Fez1 expression | |||||||||||||||
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Our results showed that Fez1 protein expression was undetectable in six of the eleven (55%) cases. | |||||||||||||||
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Conversely, inhibition of Fez1 expression stimulated cells growth [22]. | |||||||||||||||
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Overall 64% of the cases showed absence or reduction of Fez1 expression. | |||||||||||||||
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In addition, reduced Fez1 expression is associated with high-grade transitional cell carcinoma of the bladder [21]. | |||||||||||||||
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Recent studies have shown that the introduction of FEZ1 into Fez1 null cancer cells reduced cell growth with the accumulation of cells at late S to G2/M phase of the cell cycle. | |||||||||||||||
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Our results suggest that Fez1 expression may be associated to both clinical-pathological features and survival in patients with CDC. | |||||||||||||||
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In our study, we found loss of Fez1 expression in the majority of CDCs studied and a correlation with the presence of lymph node metastasis. | |||||||||||||||
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To improve our understanding of the biology of CDC and to explore the possibility that different genes may be involved in the etiology and prognosis of this neoplasm, we analyzed by immunohistochemistry eleven cases of CDC for the expression of five genes (Fez1, Fhit, p53, p27, and bcl2) often involved in the development of many common cancers. | |||||||||||||||
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Our results suggest a potential association between FEZ1 expression and CDC pathology and prognosis. | |||||||||||||||
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Here, we have reported the results of our immunohistochemical analysis of the expression of five genes (FEZ1, FHIT, P53, P27kip1, and BCL2) in a relatively large series of CDCs (eleven cases), considering the rarity of this tumor. | |||||||||||||||
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Results showed that Fez1 protein expression was undetectable or substantially reduced in 7 of the 11 (64%) cases. | |||||||||||||||
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In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2).
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