INT179036

Context Info Confidence 0.70 First Reported 2004 Last Reported 2004 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 13 Disease Relevance 13.28 Pain Relevance 0.11

transport (Fez1) mitochondrion (Fez1) plasma membrane (Fez1) cytoskeleton (Fez1) cytoplasm (Fez1)

Anatomy Link Frequency lymph node 1 bladder 1 Fez1 (Mus musculus)

Pain Link Frequency Relevance Heat medulla 26 75.84 cva 13 42.04 Inflammation 13 31.84 pain flank 13 25.80

Disease Link Frequency Relevance Heat Renal Cancer 65 100.00 Carcinoma 455 99.82 Cancer 598 99.64 Transitional Cell Carcinoma 52 98.76 Stomach Cancer 13 98.76 Metastasis 130 96.68 Solid Tumor 39 96.20 Reprotox - General 1 26 93.68 Renal Cell Carcinoma 169 93.32 Malignant Neoplastic Disease 26 87.84

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Fez1 expression

Gene_expression (expression) of Fez1

1) Confidence 0.70 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.92 Pain Relevance 0.04

Our results showed that Fez1 protein expression was undetectable in six of the eleven (55%) cases.

Gene_expression (expression) of Fez1

2) Confidence 0.70 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.93 Pain Relevance 0.04

Conversely, inhibition of Fez1 expression stimulated cells growth [22].

Gene_expression (expression) of Fez1

3) Confidence 0.70 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.11 Pain Relevance 0

Overall 64% of the cases showed absence or reduction of Fez1 expression.

Gene_expression (expression) of Fez1

4) Confidence 0.70 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.87 Pain Relevance 0.03

In addition, reduced Fez1 expression is associated with high-grade transitional cell carcinoma of the bladder [21].

Gene_expression (expression) of Fez1 in bladder associated with transitional cell carcinoma

5) Confidence 0.70 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.14 Pain Relevance 0

Recent studies have shown that the introduction of FEZ1 into Fez1 null cancer cells reduced cell growth with the accumulation of cells at late S to G2/M phase of the cell cycle.

Gene_expression (introduction) of FEZ1 associated with cancer

6) Confidence 0.60 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.11 Pain Relevance 0

Our results suggest that Fez1 expression may be associated to both clinical-pathological features and survival in patients with CDC.

Gene_expression (expression) of Fez1 associated with carcinoma

7) Confidence 0.54 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.21 Pain Relevance 0

In our study, we found loss of Fez1 expression in the majority of CDCs studied and a correlation with the presence of lymph node metastasis.

Gene_expression (expression) of Fez1 in lymph node associated with metastasis

8) Confidence 0.54 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.25 Pain Relevance 0

To improve our understanding of the biology of CDC and to explore the possibility that different genes may be involved in the etiology and prognosis of this neoplasm, we analyzed by immunohistochemistry eleven cases of CDC for the expression of five genes (Fez1, Fhit, p53, p27, and bcl2) often involved in the development of many common cancers.

Spec (analyzed) Gene_expression (expression) of Fez1 associated with cancer and carcinoma

9) Confidence 0.54 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.13 Pain Relevance 0

Our results suggest a potential association between FEZ1 expression and CDC pathology and prognosis.

Gene_expression (expression) of FEZ1 associated with carcinoma

10) Confidence 0.54 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.10 Pain Relevance 0

Here, we have reported the results of our immunohistochemical analysis of the expression of five genes (FEZ1, FHIT, P53, P27kip1, and BCL2) in a relatively large series of CDCs (eleven cases), considering the rarity of this tumor.

Gene_expression (expression) of FEZ1 associated with cancer

11) Confidence 0.54 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.10 Pain Relevance 0

Results showed that Fez1 protein expression was undetectable or substantially reduced in 7 of the 11 (64%) cases.

Gene_expression (expression) of Fez1

12) Confidence 0.54 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.68 Pain Relevance 0

In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2).

Gene_expression (expression) of FEZ1 associated with cancer and renal cancer

13) Confidence 0.54 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.72 Pain Relevance 0

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