INT179037

Context Info Confidence 0.39 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 3.52 Pain Relevance 0.06

transport (Fez1) mitochondrion (Fez1) plasma membrane (Fez1) cytoskeleton (Fez1) cytoplasm (Fez1)

Anatomy Link Frequency lymph node 3 Fez1 (Mus musculus)

Pain Link Frequency Relevance Heat medulla 8 60.80 Inflammation 4 5.00 cva 4 5.00 pain flank 4 5.00

Disease Link Frequency Relevance Heat Metastasis 40 99.40 Cancer 184 94.84 Carcinoma 140 80.68 Solid Tumor 12 78.72 Stomach Cancer 4 74.08 Transitional Cell Carcinoma 16 69.12 Renal Cancer 20 55.56 Chromosome Aberrations 4 55.48 Thyroid Neoplasm 4 47.60 Renal Cell Carcinoma 52 46.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, lack of Fez1 protein correlated with a poorer prognosis in 90% of patients with median survival of 17 months.

Negative_regulation (lack) of Fez1

1) Confidence 0.39 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.23 Pain Relevance 0

Statistical analysis showed a statistical trend (P = 0.06) between loss and reduction of Fez1 and presence of lymph node metastases.

Negative_regulation (reduction) of Fez1 in lymph node associated with metastasis

2) Confidence 0.39 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.50 Pain Relevance 0

Loss and reduction of Fez1 were correlated with a higher prevalence of lymph node metastases (71% vs. 0%, p = 0.061), although the same was not true for distant metastases or tumor stage.

Negative_regulation (reduction) of Fez1 in lymph node associated with cancer and metastasis

3) Confidence 0.34 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.89 Pain Relevance 0.03

Loss and reduction of Fez1 were correlated with a higher prevalence of lymph node metastases (71% vs. 0%, p = 0.061), although the same was not true for distant metastases or tumor stage.

Negative_regulation (Loss) of Fez1 in lymph node associated with cancer and metastasis

4) Confidence 0.34 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.90 Pain Relevance 0.03

General Comments

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