INT179039

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.07
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fez1) mitochondrion (Fez1) plasma membrane (Fez1)
cytoskeleton (Fez1) cytoplasm (Fez1)
Anatomy Link Frequency
lymph node 2
bladder 2
Fez1 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 12 74.24 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
pain flank 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 6 99.08 Very High Very High Very High
Cancer 276 99.00 Very High Very High Very High
Transitional Cell Carcinoma 24 98.76 Very High Very High Very High
Metastasis 60 96.68 Very High Very High Very High
Solid Tumor 18 96.52 Very High Very High Very High
Carcinoma 210 94.12 High High
Breast Cancer 6 86.88 High High
Reprotox - General 1 12 84.64 Quite High
Renal Cancer 30 80.92 Quite High
Renal Cell Carcinoma 78 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall 64% of the cases showed absence or reduction of Fez1 expression.
Negative_regulation (reduction) of Gene_expression (expression) of Fez1
1) Confidence 0.52 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.88 Pain Relevance 0.03
Conversely, inhibition of Fez1 expression stimulated cells growth [22].
Negative_regulation (inhibition) of Gene_expression (expression) of Fez1
2) Confidence 0.52 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.11 Pain Relevance 0
In addition, reduced Fez1 expression is associated with high-grade transitional cell carcinoma of the bladder [21].
Negative_regulation (reduced) of Gene_expression (expression) of Fez1 in bladder associated with transitional cell carcinoma
3) Confidence 0.52 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.15 Pain Relevance 0
Results showed that Fez1 protein expression was undetectable or substantially reduced in 7 of the 11 (64%) cases.
Negative_regulation (reduced) of Gene_expression (expression) of Fez1
4) Confidence 0.39 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.74 Pain Relevance 0
In our study, we found loss of Fez1 expression in the majority of CDCs studied and a correlation with the presence of lymph node metastasis.
Negative_regulation (loss) of Gene_expression (expression) of Fez1 in lymph node associated with metastasis
5) Confidence 0.39 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.26 Pain Relevance 0
Our results showed that Fez1 protein expression was undetectable in six of the eleven (55%) cases.
Negative_regulation (undetectable) of Gene_expression (expression) of Fez1
6) Confidence 0.38 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.94 Pain Relevance 0.04

General Comments

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