INT17904

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Context Info
Confidence 0.39
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.91
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
Heart 1
Hts (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 36 68.12 Quite High
depression 2 50.16 Quite High
Serotonin 15 50.00 Quite Low
Potency 5 31.84 Quite Low
anesthesia 4 25.00 Low Low
Analgesic 3 25.00 Low Low
fluoxetine 27 5.00 Very Low Very Low Very Low
Endep 17 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 100.00 Very High Very High Very High
Pneumonia 63 99.12 Very High Very High Very High
Targeted Disruption 9 98.80 Very High Very High Very High
Staphylococcus Infection 57 98.32 Very High Very High Very High
Pressure Volume 2 Under Development 3 97.66 Very High Very High Very High
Sprains And Strains 55 96.88 Very High Very High Very High
Disease 20 96.68 Very High Very High Very High
Infection 43 91.76 High High
Bacterial Pneumonia 3 60.76 Quite High
Bacterial Respiratory Disease 3 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite an initial period of hypotension after rapid infusion of HTS, mean arterial blood pressure, cardiac output, and contractility were all significantly increased at 5 min after HTS infusion.
Positive_regulation (increased) of HTS in blood associated with pressure volume 2 under development
1) Confidence 0.39 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1952141 Disease Relevance 0.22 Pain Relevance 0.03
Ultra HTS
Positive_regulation (Ultra) of HTS
2) Confidence 0.36 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.16 Pain Relevance 0
isdE mutant is functionally inactivated for both Isd and Hts-mediated heme transport.
Positive_regulation (inactivated) of Hts
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2723934 Disease Relevance 0.88 Pain Relevance 0.09
Despite the lack of involvement of Isd/Hts during the pathogenesis of pneumonia, these studies establish that S. aureus strains unable to acquire iron through either the Hts or Isd systems are severely decreased in virulence in a systemic model of infection.
Positive_regulation (involvement) of Hts associated with pneumonia, sprains and strains and infection
4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2723934 Disease Relevance 1.14 Pain Relevance 0.03
In addition, both the Hts and Isd systems are individually required for full virulence in systemic models of staphylococcal infection [2]–[4] however their combined contribution to pathogenesis has not yet been elucidated.
Positive_regulation (required) of Hts associated with staphylococcus infection
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2723934 Disease Relevance 0.26 Pain Relevance 0
We hypothesized that HTS infusions increase prostaglandin biosynthesis and that a prostaglandin synthase metabolite is responsible for mediating actions of HTS.
Positive_regulation (increase) of HTS
6) Confidence 0.16 Published 1998 Journal Shock Section Abstract Doc Link 9688088 Disease Relevance 0.05 Pain Relevance 0
Blood pressure, ACTH, and cortisol increased in response to HTS, and these responses were prevented by flunixin.
Positive_regulation (increased) of HTS in Blood
7) Confidence 0.15 Published 1998 Journal Shock Section Abstract Doc Link 9688088 Disease Relevance 0.10 Pain Relevance 0
Heart rate increased in response to HTS infusion, and flunixin reduced but did not prevent a heart rate response.
Positive_regulation (increased) of HTS in Heart associated with heart rate under development
8) Confidence 0.15 Published 1998 Journal Shock Section Abstract Doc Link 9688088 Disease Relevance 0.10 Pain Relevance 0
Automated primary HTS using L. major drug susceptibility assay
Positive_regulation (Automated) of HTS
9) Confidence 0.05 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2765639 Disease Relevance 0 Pain Relevance 0

General Comments

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