INT179043

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.99
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 96.80 Very High Very High Very High
antagonist 9 93.04 High High
agonist 22 89.24 High High
cINOD 10 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
pain flank 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cell Carcinoma 39 99.34 Very High Very High Very High
Breast Cancer 113 99.24 Very High Very High Very High
Cancer 429 98.84 Very High Very High Very High
Transitional Cell Carcinoma 12 98.04 Very High Very High Very High
Injury 5 97.08 Very High Very High Very High
INFLAMMATION 16 96.80 Very High Very High Very High
Apoptosis 49 94.76 High High
Urinary Tract Cancer 3 94.64 High High
Solid Tumor 10 93.60 High High
Mantle-cell Lymphoma 33 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In renal cell carcinoma, Kamai et al. reported that low level of p27 protein was associated with tumor invasion and unfavorable prognosis, suggesting p27 as a powerful prognostic marker for survival in urinary tract cancer [32].
Negative_regulation (level) of p27 associated with cancer, renal cell carcinoma and urinary tract cancer
1) Confidence 0.36 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.26 Pain Relevance 0.04
Our results show that p27 loss or subcellular compartmentalization represents a frequent feature in CDCs.
Negative_regulation (loss) of p27
2) Confidence 0.36 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.39 Pain Relevance 0.04
It has been suggested that loss of the p27 negative cell cycle regulation may contribute to oncogenesis and tumor progression in several tumor types.
Negative_regulation (loss) of p27 associated with cancer
3) Confidence 0.35 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.32 Pain Relevance 0.05
Shortened survival of basal-like breast cancer patients was closely associated with decreases in nuclear p27 [7,47].
Negative_regulation (decreases) of p27 associated with breast cancer
4) Confidence 0.17 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.84 Pain Relevance 0.09
Recent data show FOXO3a directly regulates p27kip1 transcription [53], [54], suggesting that reduced p27kip1 levels after a proliferative stimulus may also be associated with FOXO3a.
Negative_regulation (reduced) of p27kip1
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.22 Pain Relevance 0
Thus, the decrease in p-p27Kip1 with the treatments could be due to the low Cdk2 kinase activity.
Negative_regulation (decrease) of p27Kip1
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.14 Pain Relevance 0
CDIM9 increased p27 expression level in MDA-MB231 cells in a concentration-dependent manner.
Negative_regulation (level) of p27
7) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.24 Pain Relevance 0
These effects are mediated by nuclear accumulation of the p27(Kip1) inhibitor induced by the downregulation of the p45(Skp2) and Cks1 proteins, which target p27(Kip1) for degradation.
Negative_regulation (inhibitor) of p27
8) Confidence 0.06 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.56 Pain Relevance 0

General Comments

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