INT179044

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.64
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 96.32 Very High Very High Very High
cINOD 2 93.84 High High
Potency 1 69.60 Quite High
adenocard 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 78 99.90 Very High Very High Very High
Cancer 193 98.60 Very High Very High Very High
Injury 1 96.60 Very High Very High Very High
INFLAMMATION 3 96.32 Very High Very High Very High
Apoptosis 62 94.28 High High
Renal Cell Carcinoma 13 93.60 High High
Solid Tumor 3 93.12 High High
Urinary Tract Cancer 1 77.68 Quite High
Carcinoma 36 77.32 Quite High
Transitional Cell Carcinoma 4 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that loss of the p27 negative cell cycle regulation may contribute to oncogenesis and tumor progression in several tumor types.
Regulation (regulation) of p27 associated with cancer
1) Confidence 0.22 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.33 Pain Relevance 0.05
B, regulate p27Kip1 promoter activity [58], [59].
Regulation (regulate) of p27Kip1
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.15 Pain Relevance 0.09
Since we observed p27Kip1 upregulation with decreased cell proliferation and G0/G1 phase arrest with the depletion of cathepsin B and uPAR, we next determined the expression of FOXO proteins, which are important transcriptional regulators of the p27Kip1 promoter.
Regulation (regulators) of p27Kip1
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
This blockage of S-phase entry combined with the enhanced cyclinD1 and decreased P27 expression in SMMC-7721 cells conversely substantiated the effect of CIAPIN1 overexpression on HCC, by regulating cyclinD1 and P27 to activate expression of genes necessary for entering into the S phase.
Regulation (regulating) of P27 associated with hepatocellular cancer
4) Confidence 0.08 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.10 Pain Relevance 0.03
TSC1–2 is also proposed to function in cell-cycle control by regulating the cyclin-dependent kinase inhibitor p27 [93]. p27 protein levels are regulated through ubiquitin-dependent degradation [94].
Regulation (regulating) of cyclin-dependent kinase inhibitor p27
5) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.05 Pain Relevance 0

General Comments

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