INT179045

Context Info Confidence 0.04 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.42 Pain Relevance 0

Golgi apparatus (BLZF1) enzyme binding (BLZF1) DNA binding (BLZF1) cytoplasm (BLZF1) cell proliferation (BLZF1) vesicle-mediated transport (BLZF1)

Anatomy Link Frequency nucleus 1 reticulum 1 BLZF1 (Homo sapiens)

Pain Link Frequency Relevance Heat backache 66 50.00 imagery 20 5.00 Pain 14 5.00 member 8 2 5.00 medulla 2 5.00 Paresthesia 1 5.00 withdrawal 1 5.00 depression 1 5.00 Inflammation 1 5.00 pain flank 1 5.00

Disease Link Frequency Relevance Heat Hodgkin's Disease 154 99.84 Anaplastic Large Cell Lymphoma 38 99.56 Lymphatic System Cancer 50 99.12 Toxicity 4 91.80 Cancer 54 90.72 Metastasis 10 76.40 Carcinoma 35 75.00 Shock 2 74.80 Renal Cancer 5 66.76 Renal Cell Carcinoma 13 57.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SEG, JEM, JMG, DSM, JLK, BFW, DAO, and SDF conceptualised and designed the study, and secured funding; SEG was the lead investigator of the funding application.

Gene_expression (conceptualised) of JEM

1) Confidence 0.04 Published 2010 Journal Implement Sci Section Body Doc Link PMC2994785 Disease Relevance 0 Pain Relevance 0

Anti-R23.1 and anti-R24.1 MAbs recognise a 21 kDa plasma membrane and cytoplasmic protein expressed by HL and aggressive NHL that is identical to CYB5B, a protein that has been putatively named as an outer membrane mitochondrial protein based on partial similarities to CYB5A, an endoplasmic reticulum tail-anchored protein and high sequence identity with rat outer membrane mitochondrial protein rOM b5.

Gene_expression (expressed) of cytoplasmic protein in reticulum associated with lymphatic system cancer and hodgkin's disease

2) Confidence 0.02 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.09 Pain Relevance 0

We recently described a novel 21 kDa cell surface and cytoplasmic protein expressed by HL and ALCL cell lines, other CD30+ non-Hodgkin lymphoma cell lines, HRS cells in HL clinical biopsies, and the neoplastic cells in biopsies from ALCL and aggressive NHL patients[24].

Gene_expression (expressed) of cytoplasmic protein associated with lymphatic system cancer, anaplastic large cell lymphoma and hodgkin's disease

3) Confidence 0.02 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.64 Pain Relevance 0

Five of the six remaining cases (90%) showed exclusively cytoplasmic protein expression, where, in the last case, p27 protein was detected in both nucleus and cytoplasm.

Gene_expression (expression) of cytoplasmic protein in nucleus

4) Confidence 0.01 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.69 Pain Relevance 0

General Comments

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