INT17905

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Context Info
Confidence 0.05
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.79
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgg) extracellular space (Fgg) extracellular region (Fgg)
protein binding, bridging (Fgg)
Anatomy Link Frequency
platelet 6
Blood 1
Fgg (Mus musculus)
Pain Link Frequency Relevance Heat
epidural 5 97.32 Very High Very High Very High
cva 11 97.28 Very High Very High Very High
anesthesia 6 96.96 Very High Very High Very High
analgesia 10 96.36 Very High Very High Very High
Opioid 1 91.04 High High
Inflammation 14 90.96 High High
Pain 4 90.68 High High
Percutaneous transluminal coronary angioplasty 3 90.36 High High
Angina 3 89.92 High High
agonist 10 79.20 Quite High
Disease Link Frequency Relevance Heat
Anaemia 1 100.00 Very High Very High Very High
Renal Failure 3 98.64 Very High Very High Very High
Disease 38 98.40 Very High Very High Very High
Atherosclerosis 5 98.18 Very High Very High Very High
Cv General 3 Under Development 11 97.28 Very High Very High Very High
Abscess 126 96.24 Very High Very High Very High
Thrombosis 6 94.60 High High
Vasculitis 2 94.56 High High
Hematuria 1 94.32 High High
Coagulation Disorder 38 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blood samples for IL-6, CRP, and fibrinogen were transported to the laboratory on water ice, centrifuged to obtain serum and EDTA-anticoagulated plasma, and stored at ?
fibrinogen Binding (samples) of in Blood
1) Confidence 0.05 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.92 Pain Relevance 0.06
We conclude that in patients with atherosclerotic vascular disease undergoing arterial reconstructive surgery (a) thromboelastographic evidence of increased platelet-fibrinogen interaction is associated with early postoperative thrombotic events, and (b) epidural anesthesia and analgesia is associated with beneficial effects on coagulation status and postoperative outcome compared with intermittent on-demand opioid analgesia.
platelet-fibrinogen Binding (interaction) of in platelet associated with anesthesia, atherosclerosis, epidural, opioid and analgesia
2) Confidence 0.02 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1952169 Disease Relevance 0.59 Pain Relevance 1.05
A murine monoclonal antibody that binds to and blocks the IIb/IIIa receptor inhibits the binding of fibrinogen to platelets and thus inhibits platelet aggregation.
fibrinogen Binding (binding) of in platelet
3) Confidence 0.02 Published 1998 Journal BioDrugs Section Abstract Doc Link 18020584 Disease Relevance 0.17 Pain Relevance 0.12
Staphylococcal binding to fibrinogen or fibrin is an important attribute of disease pathogenesis, which leads to the formation of abscesses and bacterial persistence in host tissues.
fibrinogen Binding (binding) of associated with abscess and disease
4) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2916881 Disease Relevance 1.06 Pain Relevance 0
Nevertheless, association of the tetrameric (Coa·prothrombin)2 complex enables fibrinogen binding at a new site with high affinity [19].
fibrinogen Binding (binding) of
5) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.20 Pain Relevance 0
Glycoprotein IIb/IIIa has low affinity for its soluble ligands (fibrinogen and von Willebrand factor) in resting platelets.
fibrinogen Binding (ligands) of in platelets
6) Confidence 0.01 Published 2002 Journal Crit. Care Med. Section Abstract Doc Link 12004256 Disease Relevance 0.36 Pain Relevance 0.17
Hematological tests show: mild anemia with leucocytosis; prolonged PT, PTT and ThT; decreased fibrinogen, factor V, factor XIII, plasminogen and alpha2-antiplasmin levels; increased factor VIII:c, von Willebrand factor, and FDPs/D-dimers levels with normal ATIII and platelets.
fibrinogen Binding (anemia) of in platelets associated with anaemia
7) Confidence 0.01 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.73 Pain Relevance 0.14
3 interacts with fibrinogen and is the main responsible for platelet aggregation.
fibrinogen Binding (interacts) of in platelet
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.19 Pain Relevance 0
Binding of platelets to monocytes and neutrophils results in expression of the integrin CD11b/CD18 which enables further aggregate formation by interaction with the GPIb receptor on platelets [6], alternatively with fibrinogen bound to the GPIIb/IIIa receptor [7] expressed on activated platelets.
fibrinogen Binding (bound) of in platelets
9) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.58 Pain Relevance 0.14

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