INT179062

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.68
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 12
lymphoid tissue 2
cytotoxic T lymphocytes 2
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 35 98.32 Very High Very High Very High
Demyelination 123 96.88 Very High Very High Very High
cytokine 51 96.56 Very High Very High Very High
Spinal cord 33 91.72 High High
Inflammation 57 60.56 Quite High
tolerance 19 50.00 Quite Low
anesthesia 6 15.24 Low Low
Potency 2 11.60 Low Low
Multiple sclerosis 22 5.00 Very Low Very Low Very Low
Neuritis 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 21 99.60 Very High Very High Very High
Bacterial Infection 5 99.40 Very High Very High Very High
Mycobacterial Infection 19 97.84 Very High Very High Very High
Cancer 68 97.00 Very High Very High Very High
Demyelinating Disease 229 96.88 Very High Very High Very High
Herpes Simplex Virus 23 95.44 Very High Very High Very High
Influenza Virus Infection 67 95.20 Very High Very High Very High
Immunotherapy Of Cancer 4 93.12 High High
Sprains And Strains 88 90.64 High High
Diabetes Mellitus 14 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using DNA microarray analysis, Keino et al[17] compared patterns of gene expression in regulatory OT-1 CD8+T cells generated in vitro with those from nonregulatory OT-1 CD8+T cells.
Positive_regulation (generated) of Positive_regulation (nonregulatory) of CD8 in T cells
1) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.18 Pain Relevance 0
The results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Positive_regulation (effect) of Positive_regulation (increase) of CD8 in T cells associated with immunization
2) Confidence 0.40 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.17 Pain Relevance 0.09
Surprisingly, anti-IL-2 treatment enhanced the accumulation of Clone 4 CD8+ T cell in the lymphoid tissue (Fig. 3B).
Positive_regulation (enhanced) of Positive_regulation (accumulation) of CD8 in lymphoid tissue
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.57 Pain Relevance 0
Conversely, both of the less acute bacterial infection patient groups showed normal CD8+ T activation, but an increased level in the CD4+ T cells, with significance for the Tb (tuberculosis) group at p < 0.02.
Positive_regulation (increased) of Positive_regulation (activation) of CD8 in T cells associated with mycobacterial infection and bacterial infection
4) Confidence 0.18 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 1.29 Pain Relevance 0
+ T cells in samples stimulated with no peptide from the frequency of CD8+ IFN-?
Neg (no) Positive_regulation (stimulated) of Positive_regulation (frequency) of CD8 in T cells
5) Confidence 0.12 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.42 Pain Relevance 0.03
CD4+ T cells are necessary for proper CD8+ T cell activation, survival, and retention in the infected CNS [75].
Positive_regulation (necessary) of in T cells Positive_regulation (activation) of CD8 in T cell associated with central nervous system
6) Confidence 0.09 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 1.30 Pain Relevance 0.62
Decreased capacity of the heterosubtypic immunity is correlated with significantly reduced magnitude of the cross-reactive memory CD8 T cell response to the NP366/Db variants
Positive_regulation (variants) of Positive_regulation (response) of CD8 in T cell
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.65 Pain Relevance 0
Proteins encoded by DNA vaccines are expressed in the cytoplasm and presented through the endogenous processing pathway associated with MHC Class I molecules, thereafter leading to the activation of CD8 + cytotoxic T lymphocytes (CTL) [1,2], which act as effectors in the anti-tumor immune response.
Positive_regulation (leading) of Positive_regulation (activation) of CD8 in cytotoxic T lymphocytes associated with cancer
8) Confidence 0.07 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 1.09 Pain Relevance 0

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