INT179079

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
stem cell 1
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 18.72 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Tumor 60 98.84 Very High Very High Very High
Cancer 142 95.64 Very High Very High Very High
Apoptosis 53 95.40 Very High Very High Very High
Glioma 45 84.44 Quite High
Malignant Neoplastic Disease 11 83.56 Quite High
Glioblastoma 18 81.68 Quite High
Liver Cancer 10 77.80 Quite High
Stress 10 65.00 Quite High
Infection 41 60.44 Quite High
Hypertrophy 4 55.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of p53 Function Cooperates with MYC to Induce Tumorigenesis in Adult Mice
Negative_regulation (Loss) of MYC
1) Confidence 0.37 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.87 Pain Relevance 0
In fact, c-Myc is required for brain tumor stem cell growth [110], and in normal neural stem cells, loss of c-Myc on its own attenuates self-renewal and induces differentiation towards the glial lineage [111].
Negative_regulation (loss) of Myc in stem cell associated with brain tumor
2) Confidence 0.12 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.94 Pain Relevance 0
RIa-CT/COS-1 cells was significantly reduced, although the binding of bacteria to these cells was decreased by only 30% compared to Myc-hFc?
Negative_regulation (decreased) of Myc
3) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.11 Pain Relevance 0

General Comments

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