INT179080

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2004
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 5.20
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
hepatocytes 10
livers 2
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 9 52.96 Quite High
alcohol 18 10.12 Low Low
ketamine 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 252 99.96 Very High Very High Very High
Hyperplasia 144 99.56 Very High Very High Very High
Targeted Disruption 162 98.56 Very High Very High Very High
Cancer 630 97.80 Very High Very High Very High
Apoptosis 234 92.24 High High
Liver Cancer 90 77.24 Quite High
Polyploidy 9 75.12 Quite High
Aging 27 70.32 Quite High
Malignant Neoplastic Disease 54 60.52 Quite High
Lymphatic System Cancer 9 58.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We speculated that loss of p53 function might be similarly required for MYC activation to induce cell proliferation and tumorigenesis in hepatocytes.
Positive_regulation (required) of Positive_regulation (activation) of MYC in hepatocytes
1) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.74 Pain Relevance 0
We conclude that MYC activation induces endoreduplication of the genomes of normal adult hepatocytes.
Positive_regulation (induces) of Positive_regulation (activation) of MYC in hepatocytes
2) Confidence 0.50 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.17 Pain Relevance 0
If MYC were capable of enforcing mitotic division as well as cell growth and DNA replication, then aberrant activation of MYC alone would be sufficient to induce tumorigenesis.
Positive_regulation (induce) of Positive_regulation (activation) of MYC
3) Confidence 0.50 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.30 Pain Relevance 0
In adult hepatocytes, MYC activation failed to induce cell division, which was at least in part mediated through the activation of p53.
Neg (failed) Positive_regulation (induce) of Positive_regulation (activation) of MYC in hepatocytes
4) Confidence 0.50 Published 2004 Journal PLoS Biology Section Abstract Doc Link PMC519000 Disease Relevance 0.55 Pain Relevance 0
Hence, the consequences of MYC activation appear to depend on the previous commitment of cells in a specific developmental state to a cellular program capable only of growth versus growth and cellular proliferation.
Positive_regulation (depend) of Positive_regulation (activation) of MYC associated with hyperplasia
5) Confidence 0.47 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.41 Pain Relevance 0
These results highlight that the activation of MYC alone is not sufficient to induce HCC.
Positive_regulation (induce) of Positive_regulation (activation) of MYC associated with hepatocellular cancer
6) Confidence 0.47 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.14 Pain Relevance 0
We found by Northern analysis that the p53 target genes, p21 and MDM2, were induced upon MYC activation in adult livers (Figure 10C).
Positive_regulation (induced) of Positive_regulation (activation) of MYC in livers
7) Confidence 0.47 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.63 Pain Relevance 0
Hence, in adult hepatocytes, loss of p53 function appears to be necessary to permit MYC activation to induce cellular proliferation and tumorigenesis.
Positive_regulation (necessary) of Positive_regulation (activation) of MYC in hepatocytes associated with hyperplasia
8) Confidence 0.47 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.82 Pain Relevance 0.03
In contrast, upon MYC activation the proportion of neonatal hepatocytes with 2N–4N DNA content substantially increased, suggesting that an increased number of cells were in S phase (Figure 4E).
Positive_regulation (increased) of Positive_regulation (activation) of MYC in hepatocytes
9) Confidence 0.47 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.43 Pain Relevance 0

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