INT179081

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
somatic cells 2
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 38.84 Quite Low
imagery 10 33.92 Quite Low
alcohol 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 27 96.08 Very High Very High Very High
Aging 3 91.56 High High
Hyperplasia 19 87.16 High High
Cancer 148 86.16 High High
Pressure And Volume Under Development 2 75.76 Quite High
Malignant Neoplastic Disease 6 74.60 Quite High
Hepatocellular Cancer 34 68.16 Quite High
Hepatitis 3 60.44 Quite High
Liver Cancer 14 55.04 Quite High
Targeted Disruption 24 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we have provided evidence for a different mechanism: The aberrant activation of proto-oncogenes, such as MYC, in the developmental context of adult somatic cells appears to be inherently prohibited from inducing mitotic division.
Negative_regulation (prohibited) of Positive_regulation (activation) of MYC in somatic cells
1) Confidence 0.37 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.88 Pain Relevance 0
C-MYC induction preceded integrase expression because the integrase protein can only be detected by Western blot for up to one day after hydrodynamic injection [39].
Negative_regulation (preceded) of Positive_regulation (induction) of MYC
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894073 Disease Relevance 0.39 Pain Relevance 0

General Comments

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