INT179083

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 65
Total Number 67
Disease Relevance 38.78
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
hepatocytes 24
liver 7
somatic cells 1
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 72.00 Quite High
alcohol 118 71.20 Quite High
Central nervous system 59 52.96 Quite High
addiction 2 41.20 Quite Low
imagery 10 33.20 Quite Low
ketamine 60 5.00 Very Low Very Low Very Low
Pain 59 5.00 Very Low Very Low Very Low
fibrosis 13 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4609 100.00 Very High Very High Very High
Hyperplasia 951 99.96 Very High Very High Very High
Colorectal Cancer 58 99.78 Very High Very High Very High
Hepatocellular Cancer 1658 98.60 Very High Very High Very High
Apoptosis 1585 98.56 Very High Very High Very High
Hypertrophy 236 98.24 Very High Very High Very High
Targeted Disruption 1202 97.84 Very High Very High Very High
Liver Cancer 597 97.28 Very High Very High Very High
Sprains And Strains 10 96.52 Very High Very High Very High
Malignant Neoplastic Disease 365 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumorigenic conversion of hepatocytes was associated, in all age groups of mice, with further increases in the levels of MYC protein (Figure 3B).
Positive_regulation (increases) of MYC in hepatocytes
1) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.35 Pain Relevance 0
We found that MYC activation was associated with an increase in p53 protein levels in adult hepatocytes, as measured by Western analysis (Figure 10A).
Positive_regulation (activation) of MYC in hepatocytes
2) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.68 Pain Relevance 0
In adult hepatocytes, MYC activation failed to induce cell division, which was at least in part mediated through the activation of p53.
Positive_regulation (activation) of MYC in hepatocytes
3) Confidence 0.70 Published 2004 Journal PLoS Biology Section Abstract Doc Link PMC519000 Disease Relevance 0.55 Pain Relevance 0
We speculated that loss of p53 function might be similarly required for MYC activation to induce cell proliferation and tumorigenesis in hepatocytes.
Positive_regulation (activation) of MYC in hepatocytes
4) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.74 Pain Relevance 0
We expected that if adult hepatocytes were restrained from undergoing mitotic division, MYC activation might result in endoreduplication.
Positive_regulation (activation) of MYC in hepatocytes
5) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.37 Pain Relevance 0
We recognized that an alternative explanation for our results is that only hepatocytes that are actively proliferating are susceptible to neoplastic transformation upon MYC induction.
Positive_regulation (induction) of MYC in hepatocytes
6) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.40 Pain Relevance 0
However, differences in the ability of MYC activation to initiate tumorigenesis in mice of different ages did not appear to be related to differences in the levels of induction of MYC transgene expression.
Positive_regulation (activation) of MYC
7) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.49 Pain Relevance 0
MYC was activated at birth by removing doxycycline from the mating cage immediately after the birth of the litter.
Positive_regulation (activated) of MYC
8) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.39 Pain Relevance 0
MYC was activated during embryonic development by removing doxycycline treatment from the mating cage before conception.
Positive_regulation (activated) of MYC
9) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.40 Pain Relevance 0
To determine if the developmental state of host hepatocytes influenced the ability of MYC activation to induce tumorigenesis, we induced MYC in cohorts of different ages (Figure 3A).
Positive_regulation (activation) of MYC in hepatocytes
10) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.75 Pain Relevance 0
If MYC were capable of enforcing mitotic division as well as cell growth and DNA replication, then aberrant activation of MYC alone would be sufficient to induce tumorigenesis.
Positive_regulation (activation) of MYC
11) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.30 Pain Relevance 0
We conclude that MYC activation induces endoreduplication of the genomes of normal adult hepatocytes.
Positive_regulation (activation) of MYC in hepatocytes
12) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.17 Pain Relevance 0
In neonatal and adult mice, MYC protein levels were induced at similar levels (Figure 3B).
Positive_regulation (induced) of MYC
13) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.59 Pain Relevance 0
To evaluate how MYC's ability to induce tumorigenesis is influenced by the age of mice, we investigated the initial consequences of MYC activation in hepatocytes during different developmental periods.
Spec (investigated) Positive_regulation (activation) of MYC in hepatocytes
14) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.54 Pain Relevance 0
MYC oncogene activation is one of the more common events in the pathogenesis of HCC.
Positive_regulation (activation) of MYC associated with hepatocellular cancer
15) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.59 Pain Relevance 0.04
To further define the consequences of MYC activation on the cell cycle, we examined the DNA content of isolated nuclei from normal and MYC-activated adult hepatocytes.
Positive_regulation (activation) of MYC in hepatocytes
16) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.41 Pain Relevance 0
Hence, the consequences of MYC activation appear to depend on the previous commitment of cells in a specific developmental state to a cellular program capable only of growth versus growth and cellular proliferation.
Positive_regulation (activation) of MYC associated with hyperplasia
17) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.41 Pain Relevance 0
First, we examined if MYC activation affected p53 protein expression.
Spec (examined) Positive_regulation (activation) of MYC
18) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.68 Pain Relevance 0
Contrary to what we expected, MYC activation was only associated with increased apoptosis in the hepatocytes of liver cancers (Figure 9C, 9D, 9I, and 9J).
Positive_regulation (activation) of MYC in liver associated with liver cancer and apoptosis
19) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.26 Pain Relevance 0
We conclude that MYC activation during embryonic development causes neonatal hepatocytes to undergo DNA replication, cell cycle transit, proliferation, and almost immediate neoplastic conversion.
Positive_regulation (activation) of MYC in hepatocytes
20) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.50 Pain Relevance 0

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