INT179085

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.83
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
stem cell 1
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 62.92 Quite High
withdrawal 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 108 99.62 Very High Very High Very High
Hepatocellular Cancer 34 99.06 Very High Very High Very High
Brain Tumor 60 97.52 Very High Very High Very High
Cancer 235 97.32 Very High Very High Very High
Glioma 45 96.96 Very High Very High Very High
Malignant Neoplastic Disease 11 96.08 Very High Very High Very High
Glioblastoma 18 94.20 High High
Hyperplasia 23 90.08 High High
Injury 4 87.52 High High
Stress 8 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myc is a potent oncogene that regulates gene expression by binding cognate DNA sequences as a heterodimer with a related protein Max [48].
Regulation (regulates) of Myc
1) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.08 Pain Relevance 0
These data show that TERT controls tissue progenitor cells via transcriptional regulation of a developmental program converging on the Myc and Wnt pathways.


Regulation (regulation) of Myc
2) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2211538 Disease Relevance 0.25 Pain Relevance 0
To investigate the developmentally specific consequences of MYC overexpression in the pathogenesis of HCC in vivo, we used transgenic mice in which the MYC proto-oncogene is conditionally regulated via the tetracycline regulatory system (Tet system) (Felsher and Bishop 1999b).
Regulation (regulated) of MYC associated with targeted disruption and hepatocellular cancer
3) Confidence 0.27 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.98 Pain Relevance 0
Strikingly, GSEA comparisons revealed strong connectivity between TERT and two pathways known to regulate progenitor cells, Myc and Wnt (Figure 7A and Table S7).
Regulation (regulate) of Myc
4) Confidence 0.17 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.13 Pain Relevance 0
These results confirmed that the LAP-tTA/TRE-MYC mouse model allowed for tight oncogene regulation.
Regulation (regulation) of MYC
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894073 Disease Relevance 0.45 Pain Relevance 0.06
Therefore, targeting pluripotency-associated molecules such as Myc and Sox2, combined with reactivation of p53, specifically in brain tumor stem cell populations could become one approach to effectively reduce tumor growth.
Regulation (targeting) of Myc in stem cell associated with cancer and brain tumor
6) Confidence 0.07 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.96 Pain Relevance 0

General Comments

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