INT179088

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.23
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 84.84 Quite High
Inflammation 20 79.44 Quite High
cytokine 8 59.52 Quite High
cINOD 1 43.00 Quite Low
Central nervous system 1 41.92 Quite Low
chemokine 1 14.16 Low Low
cva 1 8.52 Low Low
fibrosis 7 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 28 96.96 Very High Very High Very High
Apoptosis 55 95.88 Very High Very High Very High
Cancer 133 90.76 High High
Aging 4 88.64 High High
Hyperplasia 17 88.08 High High
Stomach Cancer 36 83.84 Quite High
Starvation 1 80.80 Quite High
INFLAMMATION 23 79.44 Quite High
Toxicity 2 74.08 Quite High
Manic Depressive Disorder 1 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The introduction of a single mutant p53 allele greatly accelerated MYC's ability to induce tumorigenesis.
Positive_regulation (accelerated) of Regulation (introduction) of p53
1) Confidence 0.38 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.86 Pain Relevance 0
Over-expression of MIF down regulated p53 levels and suppressed nuclear localization, thereby prohibiting its transcriptional activity.
Positive_regulation (expression) of Regulation (regulated) of p53
2) Confidence 0.16 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.33 Pain Relevance 0.19
On the other hand, recent evidence suggests that HDAC inhibitors also enhance the acetylation of non-histone proteins, such as p53, c-Jun, and ?
Positive_regulation (enhance) of Regulation (acetylation) of p53
3) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 1.04 Pain Relevance 0.04

General Comments

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