INT179089

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Context Info
Confidence 0.90
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.52
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
nucleus 3
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 75 97.72 Very High Very High Very High
Osteoarthritis 36 80.96 Quite High
Inflammation 26 79.72 Quite High
Arthritis 5 37.72 Quite Low
methotrexate 4 5.36 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 193 98.92 Very High Very High Very High
Rheumatoid Arthritis 77 97.72 Very High Very High Very High
Apoptosis 296 97.36 Very High Very High Very High
Liver Cancer 10 96.32 Very High Very High Very High
Viral Infection 2 95.00 High High
Necrosis 18 94.72 High High
Dilated Cardiomyopathy 1 87.48 High High
Targeted Disruption 121 85.52 High High
Glioma 45 84.08 Quite High
Mantle-cell Lymphoma 33 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possibility is that Hr decreases levels of p53 by promoting p53 degradation through a proteosome dependent pathway. p53 has previously been shown to be deacetylated through formation of a complex with the E3 ligase MDM2[31], [32], [33], and histone deacetylates (HDAC), for example HDAC1[34], resulting in proteosomal degradation of p53 [35], or p53 export from nucleus[36].
Protein_catabolism (degradation) of p53 in nucleus
1) Confidence 0.90 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.84 Pain Relevance 0
One possibility is that Hr decreases levels of p53 by promoting p53 degradation through a proteosome dependent pathway. p53 has previously been shown to be deacetylated through formation of a complex with the E3 ligase MDM2[31], [32], [33], and histone deacetylates (HDAC), for example HDAC1[34], resulting in proteosomal degradation of p53 [35], or p53 export from nucleus[36].
Protein_catabolism (degradation) of p53 in nucleus
2) Confidence 0.90 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.63 Pain Relevance 0
The MDM4 and MDM2 proteins suppress p53's transcriptional activity and target p53 for proteasomal degradation, respectively [22].
Protein_catabolism (degradation) of p53
3) Confidence 0.89 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.29 Pain Relevance 0
One possibility is that Hr decreases levels of p53 by promoting p53 degradation through a proteosome dependent pathway. p53 has previously been shown to be deacetylated through formation of a complex with the E3 ligase MDM2[31], [32], [33], and histone deacetylates (HDAC), for example HDAC1[34], resulting in proteosomal degradation of p53 [35], or p53 export from nucleus[36].
Protein_catabolism (degradation) of p53 in nucleus
4) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.63 Pain Relevance 0
Loss of p53 heterozygosity analysis by PCR
Protein_catabolism (analysis) of p53
5) Confidence 0.66 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.43 Pain Relevance 0
Additionally we did not observe any differences in p53 protein stability (Figure S1B/C).
Protein_catabolism (stability) of p53
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.64 Pain Relevance 0
High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.
Protein_catabolism (degradation) of p53 associated with cancer
7) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.85 Pain Relevance 0
Effective degradation of p53 is mediated by the ubiquitin ligase Mdm2, as well as in RA [47], and Mdm2 can promote p53 deacetylation by recruiting a complex containing HDAC1 [48].
Protein_catabolism (degradation) of p53 associated with rheumatoid arthritis
8) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.21 Pain Relevance 0.29

General Comments

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