INT179093

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) transport (Vps54) DNA binding (Myc)
protein complex (Myc) cytoplasm (Myc) pigmentation (Myc)
Anatomy Link Frequency
hepatocytes 1
Myc (Mus musculus)
Vps54 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 3 30.88 Quite Low
alcohol 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 84 100.00 Very High Very High Very High
Targeted Disruption 54 98.84 Very High Very High Very High
Cancer 210 93.00 High High
Liver Cancer 30 90.20 High High
Apoptosis 78 89.84 High High
Hyperplasia 48 77.04 Quite High
Lymphatic System Cancer 3 68.44 Quite High
Breast Cancer 3 67.92 Quite High
Polyploidy 3 16.20 Low Low
Malignant Neoplastic Disease 18 5.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MYC-induced HCC exhibited reduced p53 protein expression and transcriptional activity.
MYC Positive_regulation (induced) of HCC associated with hepatocellular cancer
1) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.83 Pain Relevance 0
Our results extend previous findings that suggest that the lack of p53 function cooperates with MYC to induce HCC (Klocke et al. 2001).
MYC Positive_regulation (induce) of HCC associated with hepatocellular cancer
2) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.65 Pain Relevance 0
To directly address if loss of any of p53's functions accelerates the ability of MYC to induce HCC in adult mice, we generated transgenic mice that overexpressed MYC in their hepatocytes in the absence of one p53 allele.
MYC Positive_regulation (induce) of HCC in hepatocytes associated with targeted disruption and hepatocellular cancer
3) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.83 Pain Relevance 0

General Comments

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