INT179115

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.94
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
astrocytes 2
heart 2
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 14 58.12 Quite High
fibrosis 15 55.76 Quite High
cytokine 6 54.40 Quite High
Dynorphin 3 7.84 Low Low
cva 5 5.00 Very Low Very Low Very Low
opioid receptor 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 41 99.04 Very High Very High Very High
Myocardial Infarction 71 94.60 High High
Diabetes Mellitus 93 87.12 High High
Hydrocephalus 62 76.36 Quite High
Ganglion Cysts 14 58.12 Quite High
Fibrosis 16 55.76 Quite High
Ventricular Remodeling 10 50.00 Quite Low
Cicatrix 3 47.76 Quite Low
Injury 5 26.96 Quite Low
Gliosis 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the 36d shunted animals, there was a noticeable decrease in relative abundance of GFAP labeled astrocytes in the cortical layers (Fig. 2).
Negative_regulation (decrease) of Localization (abundance) of Fig in astrocytes
1) Confidence 0.33 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.13 Pain Relevance 0
0.092) towards reduced phosphorylation of AKT residue Ser473 was detected (Fig. 4B). 24 h LPS infusion had no effect on the protein level or phosphorylation state of residues Thr421 and Ser424 of p70 S6K (Fig. 4C & 4D), nor on the phosphorylation state of Thr37 and Thr46 of 4E-BP1 (Fig. 4E), where both p70 S6K and 4E-BP1 are located downstream of AKT.
Negative_regulation (downstream) of Localization (located) of Fig
2) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.03
LECs displayed perinuclear and cytoplasmic localization of VEGFR-2 and neuropilin 1 (Fig. 4).
Negative_regulation (displayed) of Localization (localization) of Fig
3) Confidence 0.14 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.42 Pain Relevance 0
We found that HuR-specific siRNA reduced Grb7 export (Fig. 2 A) and blocked EGF-stimulated cytoplasmic accumulation of Grb7 (Fig. 2 B), which was rescued by expressing siRNA off-target HuR (see Materials and methods).
Negative_regulation (reduced) of Localization (export) of Fig
4) Confidence 0.11 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.11 Pain Relevance 0.05
To analyze the angiogenic response to the therapy, the arteriolar density (in counts/mm2) was measured by immunostaining the heart tissue sections (Fig. 3C and D) after 7 days of gene therapy for ?
Negative_regulation (immunostaining) of Localization (sections) of Fig in heart
5) Confidence 0.07 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.29 Pain Relevance 0.03

General Comments

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