INT179117

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.08
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nrp1) cytosol (Nrp1) cell adhesion (Nrp1)
plasma membrane (Nrp1)
Anatomy Link Frequency
spinal cord 1
Nrp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 25 99.04 Very High Very High Very High
antagonist 1 51.44 Quite High
intrathecal 5 12.56 Low Low
Neuropathic pain 5 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 1 99.36 Very High Very High Very High
Stress 114 99.32 Very High Very High Very High
Spinal Cord Injury 57 99.18 Very High Very High Very High
Neurodegenerative Disease 3 85.36 High High
Stroke 1 76.56 Quite High
Cicatrix 3 70.00 Quite High
Injury 36 55.72 Quite High
Disorder Of Lipid Metabolism 3 25.36 Quite Low
Neuropathic Pain 7 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is evident that VEGFR-1, VEGFR-2 and neuropilin-1 levels increase following shear stress conditions.


Positive_regulation (increase) of neuropilin-1 associated with stress
1) Confidence 0.28 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.47 Pain Relevance 0
Quantification of the above receptors showed a significant increase in VEGFR-1, VEGFR-2 and neuropilin-1 mRNA following shear stress.


Positive_regulation (increase) of neuropilin-1 associated with stress
2) Confidence 0.26 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC519024 Disease Relevance 0.49 Pain Relevance 0
We also provide evidence demonstrating that shear stress imposed on LECs in vitro is accompanied by a significant increases in VEGFR-1, VEGFR-2 and neuropilin-1 mRNA levels.
Positive_regulation (increases) of neuropilin-1 associated with stress
3) Confidence 0.11 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.42 Pain Relevance 0
In the context of spinal cord injury, hypoxia inducible factor (HIF)-1 alpha activates numerous downstream effectors such as BDNF, VEGF, SDF-1, TrkB, Nrp-1, CXCR4 and NO, that attempt to restore the "neurovascular niche" after damage has occurred [43].
Positive_regulation (activates) of Nrp-1 in spinal cord associated with hypoxia and spinal cord
4) Confidence 0.06 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2989319 Disease Relevance 0.71 Pain Relevance 0.08

General Comments

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