INT17913

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2011
Negated 33
Speculated 5
Reported most in Body
Documents 87
Total Number 93
Disease Relevance 93.23
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 5
blood 4
coronary artery 2
Heart 2
body 2
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 63 100.00 Very High Very High Very High
rheumatoid arthritis 321 98.88 Very High Very High Very High
transdermal 27 98.88 Very High Very High Very High
beta blocker 26 98.76 Very High Very High Very High
methadone 3 97.24 Very High Very High Very High
corticosteroid 49 96.36 Very High Very High Very High
Inflammatory mediators 4 96.22 Very High Very High Very High
Pain 79 96.16 Very High Very High Very High
Angina 48 95.52 Very High Very High Very High
tolerance 70 94.80 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 4311 100.00 Very High Very High Very High
Coronary Artery Disease 1413 100.00 Very High Very High Very High
Diabetes Mellitus 1117 100.00 Very High Very High Very High
Cardiovascular Disease 658 100.00 Very High Very High Very High
Hyperlipidemia 380 100.00 Very High Very High Very High
Hypertension 230 100.00 Very High Very High Very High
Body Weight 152 100.00 Very High Very High Very High
Hypertriglyceridemia 136 99.84 Very High Very High Very High
Alzheimer's Dementia 5 99.76 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

410 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in the level of cholesterol, triglycerides, HDL and LDL, high-sensitive CRP, uric acid and blood pressure were assessed as secondary variables.
Regulation (Changes) of HDL in blood associated with disorder of lipid metabolism
1) Confidence 0.60 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687747 Disease Relevance 0.48 Pain Relevance 0
The treatment group experienced marked changes in HDL-C (+26%, p < 0.001) and LDL-C (?
Regulation (changes) of HDL associated with disorder of lipid metabolism
2) Confidence 0.60 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 1.52 Pain Relevance 0
In combined hypercholesterolemia subgroups serum HDL-C and VLDL-C levels were not significantly affected by any of the treatments, whereas serum LDL-C level was significantly decreased by quinazolinones treatment, compared to either bezafibrate or their reference group (Table 3).
Neg (not) Regulation (affected) of HDL associated with hyperlipidemia and disorder of lipid metabolism
3) Confidence 0.60 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.79 Pain Relevance 0
However, changes on TC and HDL-C were dependent in TAG concentration, meanwhile LDL-C values decreased after treatment in an independent way.
Regulation (changes) of HDL associated with disorder of lipid metabolism
4) Confidence 0.60 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2211748 Disease Relevance 1.26 Pain Relevance 0
None of the foregoing treatments significantly affected serum triacylglycerol, HDL-C and VLDL-C levels.
Regulation (affected) of HDL associated with disorder of lipid metabolism
5) Confidence 0.60 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.45 Pain Relevance 0
Consistent with the other RIO trials, improvements from baseline in cardiometabolic parameters also were noted, including beneficial effects on HDL cholesterol and TG.
Regulation (effects) of HDL associated with disorder of lipid metabolism
6) Confidence 0.60 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291325 Disease Relevance 0.82 Pain Relevance 0
From the results of this long-term study it can be concluded that a moderate fat diet with a P/S ratio of 2 can lower total cholesterol effectively without affecting HDL cholesterol.
Neg (without) Regulation (affecting) of HDL in fat associated with disorder of lipid metabolism
7) Confidence 0.60 Published 1987 Journal Atherosclerosis Section Abstract Doc Link 3632757 Disease Relevance 1.16 Pain Relevance 0.15
Serum free cholesterol and HDL-C levels were insignificantly changed in all treatment subgroups.
Regulation (changed) of HDL associated with disorder of lipid metabolism
8) Confidence 0.60 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.35 Pain Relevance 0
The quinazolinone compounds did not affect significantly serum HDL-C level (Table 2).
Neg (not) Regulation (affect) of HDL associated with disorder of lipid metabolism
9) Confidence 0.60 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.58 Pain Relevance 0.03
Atorvastatin also significantly reduced total and LDL cholesterol and triglyceride levels but did not significantly change high density lipoprotein (HDL) cholesterol by 16 weeks.
Neg (not) Regulation (change) of HDL associated with disorder of lipid metabolism
10) Confidence 0.60 Published 2002 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC134475 Disease Relevance 0.76 Pain Relevance 0.06
In high doses, niacin can significantly alter HDL-C, LDL-C, triglycerides, and Lp(a) in a dose-dependent manner.
Regulation (alter) of HDL associated with disorder of lipid metabolism
11) Confidence 0.60 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.56 Pain Relevance 0
A tendency for increased Tg levels and lower HDL-C concentrations was apparent during combined thiazide-type diuretic-beta-blocker treatment; these changes resembled those observed during beta-blocker monotherapy.
Regulation (tendency) of HDL associated with beta blocker and disorder of lipid metabolism
12) Confidence 0.44 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6204152 Disease Relevance 0.27 Pain Relevance 0.17
Although the major focus for the past 10 years has been LDL-C reduction with statins, many other trials have produced impressive results by targeting HDL-C or triglycerides.
Regulation (targeting) of HDL associated with disorder of lipid metabolism
13) Confidence 0.44 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 1.51 Pain Relevance 0
There was no difference in LDL-C concentration between the two HDL-C subgroups, but the VLDL-C and triglycerides concentrations were higher in the low HDL-C group (Table 3).


Neg (no) Regulation (difference) of HDL associated with disorder of lipid metabolism
14) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2940866 Disease Relevance 2.12 Pain Relevance 0.07
Soy isoflavones significantly reduced serum total and LDL-C but did not change HDL-C and triacylglyceride (45).
Neg (not) Regulation (change) of HDL associated with disorder of lipid metabolism
15) Confidence 0.44 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892343 Disease Relevance 0.84 Pain Relevance 0
Following resistance exercise training, there was an increase in CK activity, and an increase in total and LDL cholesterol (P<0.05), without a change in LDL/HDL ratio (Table 5).
Neg (without) Regulation (change) of HDL associated with disorder of lipid metabolism
16) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.25 Pain Relevance 0
However, the univariate analysis showed that the changes on HDL-C and TC concentrations were dependent on TAG concentration (p = 0.247 and p = 0.108, respectively); while LDL-C concentration was independent of TAG values (p = 0.044).
Regulation (dependent) of HDL associated with disorder of lipid metabolism
17) Confidence 0.44 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2211748 Disease Relevance 0.44 Pain Relevance 0
However, in contrast to the Strong Heart Study, the significant risk of TC/HDL-C in prediction of incident CVD was not affected by TG levels [7].
Neg (not) Regulation (affected) of HDL in Heart associated with hypertriglyceridemia, cardiovascular disease and disorder of lipid metabolism
18) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.52 Pain Relevance 0
In this study, among the diabetic population, HDL-C in both genders was not associated with incident CVD, although there was significant protective effect of HDL-C in non-diabetic men.
Regulation (effect) of HDL associated with cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
19) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2835707 Disease Relevance 3.30 Pain Relevance 0
The favorable changes in HDL-C and TG appear to be approximately double what could be attributed to weight loss (Pi-Sunyer et al. 2006), indicating a direct effect on lipid metabolism.
Regulation (changes) of HDL associated with weight loss and disorder of lipid metabolism
20) Confidence 0.44 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 0.99 Pain Relevance 0

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