INT179130

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.57
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
leukocyte 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 22 99.98 Very High Very High Very High
Inflammation 20 96.60 Very High Very High Very High
Arthritis 112 95.28 Very High Very High Very High
rheumatoid arthritis 13 85.56 High High
cytokine 35 76.36 Quite High
Pain 14 31.36 Quite Low
tolerance 1 11.84 Low Low
chemokine 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 22 99.98 Very High Very High Very High
Arthritis 127 96.84 Very High Very High Very High
Adhesions 15 93.04 High High
Mental Disorders 2 87.92 High High
Rheumatoid Arthritis 13 85.56 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 40 50.00 Quite Low
Immunization 8 45.84 Quite Low
Pain 14 31.36 Quite Low
INFLAMMATION 19 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the overall number of participants with depression appeared lower among those with CD4 ?
Spec (appeared) Negative_regulation (appeared) of CD4 Spec (appeared) Binding (those) of associated with depression
1) Confidence 0.42 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC519026 Disease Relevance 0.47 Pain Relevance 0.19
Support for this model comes from studies showing loss or inhibition of CD44 and VLA-4 (very late antigen-4) interactions with their ligands that can reduce leukocyte rolling interactions and inhibit joint inflammation in animal models of arthritis [19,20].
Negative_regulation (inhibition) of antigen-4 Binding (interactions) of in leukocyte associated with inflammation and arthritis
2) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.10 Pain Relevance 0.47

General Comments

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