INT179133

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.18
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Anatomy Link Frequency
vesicle 2
NF-1 1
Nf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 99.36 Very High Very High Very High
Dopamine 6 94.00 High High
imagery 4 91.04 High High
Hippocampus 24 77.44 Quite High
dopamine receptor 24 72.80 Quite High
gABA 21 68.28 Quite High
long-term potentiation 15 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Neurobehavioral 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Watson Syndrome 84 100.00 Very High Very High Very High
Pain 1 99.36 Very High Very High Very High
Melanoma 30 95.44 Very High Very High Very High
Neurofibromatosis 7 90.12 High High
Neurofibroma 22 86.28 High High
Malignant Neoplastic Disease 3 81.36 Quite High
Epithelioid And Spindle Cell Nevus 1 72.28 Quite High
Cognitive Disorder 54 58.12 Quite High
Targeted Disruption 18 50.00 Quite Low
Cancer 16 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction between neurofibromin and kinesins suggests a mechanism for intracellular localization of the neurofibromin/APP complex.
Localization (localization) of neurofibromin
1) Confidence 0.80 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.39 Pain Relevance 0.18
This study proposed that NF1 gene mutations impair vesicle trafficking through aberrant kinesin transport of both NF1 and APP [19].
Localization (transport) of NF1 in vesicle associated with watson syndrome
2) Confidence 0.75 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.36 Pain Relevance 0.18
This study proposed that NF1 gene mutations impair vesicle trafficking through aberrant kinesin transport of both NF1 and APP [19].
Localization (transport) of NF1 in vesicle associated with watson syndrome
3) Confidence 0.75 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.37 Pain Relevance 0.18
In September 2000, a 35-year-old female without any history or clinical stigmata of NF-1 presented to her primary physician with complaints of a dull, localized left upper leg pain of several months' duration.
Localization (localized) of NF-1 in NF-1 associated with pain
4) Confidence 0.53 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC519028 Disease Relevance 1.06 Pain Relevance 0.14

General Comments

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