INT17915

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 10
Speculated 4
Reported most in Abstract
Documents 141
Total Number 147
Disease Relevance 47.45
Pain Relevance 48.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
neurons 25
plasma 8
pituitary 7
sciatic nerve 5
brain 4
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 104 100.00 Very High Very High Very High
opioid receptor 90 100.00 Very High Very High Very High
Dynorphin 90 100.00 Very High Very High Very High
Morphine 52 100.00 Very High Very High Very High
Enkephalin 35 100.00 Very High Very High Very High
substance P 29 100.00 Very High Very High Very High
vanilloid receptor subtype 1 8 100.00 Very High Very High Very High
COX2 3 100.00 Very High Very High Very High
mu opioid receptor 19 99.98 Very High Very High Very High
Neuropeptide 43 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 88 100.00 Very High Very High Very High
Aids-related Complex 20 99.88 Very High Very High Very High
Urological Neuroanatomy 64 99.70 Very High Very High Very High
Neuropathic Pain 211 99.60 Very High Very High Very High
Ganglion Cysts 113 99.60 Very High Very High Very High
Sprains And Strains 14 99.60 Very High Very High Very High
Hemorrhagic Shock 8 99.46 Very High Very High Very High
Coronary Artery Disease 14 99.40 Very High Very High Very High
Injury 140 99.38 Very High Very High Very High
Drug Dependence 7 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The bilateral expression of Fos-IR neurons in the PBN indicates that the experimental tooth movement causes the activation of PBN neurons for the processing of somatosensory as well as autonomic information.
Gene_expression (expression) of Fos-IR in neurons
1) Confidence 0.75 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0.10 Pain Relevance 0.26
The prolonged expression of Fos-IR neurons in all the subnuclei of bilateral PBN reflects clinical features of the transient discomfort and/or abnormal sensations, which many patients often complain about during orthodontic treatment.
Gene_expression (expression) of Fos-IR in PBN
2) Confidence 0.75 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0.09 Pain Relevance 0.24
Naloxone pretreatment enhanced the expression of Fos-IR neurons on the ipsilateral SpVc.
Gene_expression (expression) of Fos-IR in neurons associated with narcan
3) Confidence 0.74 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0 Pain Relevance 0.36
These neurons were of various sizes (range= 43-1768 microm(2), mean+/-S.D.=651+/-356 microm(2)); 26% and 14% of ASIC3-immunoreactive (IR) neurons co-expressed CGRP- and PV-immunoreactivity (IR), respectively; 33% and 13% of the TG neurons retrogradely labeled from the tooth pulp and facial skin, respectively, exhibited ASIC3-IR; 36% of CGRP-IR TG neurons which innervate these tissues co-expressed ASIC3-IR.
Gene_expression (co-expressed) of ASIC3-IR in skin associated with trigeminal ganglion and calcitonin gene-related peptide
4) Confidence 0.74 Published 2002 Journal Brain Res. Section Abstract Doc Link 12101052 Disease Relevance 0.70 Pain Relevance 0.64
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Gene_expression (expressions) of IGF-IR in sciatic nerve associated with nerve growth factor and sciatic nerve
5) Confidence 0.71 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.35 Pain Relevance 0.45
Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively).
Gene_expression (expressions) of Insulin receptor in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
6) Confidence 0.71 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.39 Pain Relevance 0.48
Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively).
Gene_expression (expressions) of IGF-IR in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
7) Confidence 0.71 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.38 Pain Relevance 0.47
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Gene_expression (expressions) of insulin receptor in sciatic nerve associated with nerve growth factor and sciatic nerve
8) Confidence 0.71 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.36 Pain Relevance 0.46
IR-LE and IR-OC release was enhanced 4 h later (20:00 h), no changes were detected for IR-HE.
Neg (no) Gene_expression (detected) of IR-HE
9) Confidence 0.67 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.55
Type 1 (25-30 microm cell diameter) and type 9 (35-45 microm) expressed MOR-IR, but were negative for DOR-IR and KOR-IR.
Gene_expression (expressed) of MOR-IR
10) Confidence 0.66 Published 2005 Journal J. Chem. Neuroanat. Section Abstract Doc Link 15927787 Disease Relevance 0.17 Pain Relevance 0.45
Type 2 (25-30 microm) co-expressed DOR-IR and MOR-IR, but did not express KOR-IR.
Gene_expression (-) of DOR-IR
11) Confidence 0.66 Published 2005 Journal J. Chem. Neuroanat. Section Abstract Doc Link 15927787 Disease Relevance 0.17 Pain Relevance 0.45
Type 2 (25-30 microm) co-expressed DOR-IR and MOR-IR, but did not express KOR-IR.
Gene_expression (-) of MOR-IR
12) Confidence 0.66 Published 2005 Journal J. Chem. Neuroanat. Section Abstract Doc Link 15927787 Disease Relevance 0.17 Pain Relevance 0.46
Type 5 (35-45 microm) and type 8 (35-45 microm), co-expressed KOR-IR and MOR-IR, but did not express DOR-IR.
Gene_expression (expressed) of MOR-IR
13) Confidence 0.66 Published 2005 Journal J. Chem. Neuroanat. Section Abstract Doc Link 15927787 Disease Relevance 0.16 Pain Relevance 0.52
The bilateral expression of Fos-IR neurons in the PBN indicates that the experimental tooth movement causes the activation of PBN neurons for the processing of somatosensory as well as autonomic information.
Gene_expression (expression) of Fos-IR in neurons
14) Confidence 0.65 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0.10 Pain Relevance 0.26
The prolonged expression of Fos-IR neurons in all the subnuclei of bilateral PBN reflects clinical features of the transient discomfort and/or abnormal sensations, which many patients often complain about during orthodontic treatment.
Gene_expression (expression) of Fos-IR in PBN
15) Confidence 0.65 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0.09 Pain Relevance 0.24
Naloxone pretreatment enhanced the expression of Fos-IR neurons on the ipsilateral SpVc.
Gene_expression (expression) of Fos-IR in neurons associated with narcan
16) Confidence 0.64 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0 Pain Relevance 0.36
These neurons were of various sizes (range= 43-1768 microm(2), mean+/-S.D.=651+/-356 microm(2)); 26% and 14% of ASIC3-immunoreactive (IR) neurons co-expressed CGRP- and PV-immunoreactivity (IR), respectively; 33% and 13% of the TG neurons retrogradely labeled from the tooth pulp and facial skin, respectively, exhibited ASIC3-IR; 36% of CGRP-IR TG neurons which innervate these tissues co-expressed ASIC3-IR.
Gene_expression (co-expressed) of ASIC3-IR in skin associated with trigeminal ganglion and calcitonin gene-related peptide
17) Confidence 0.64 Published 2002 Journal Brain Res. Section Abstract Doc Link 12101052 Disease Relevance 0.70 Pain Relevance 0.64
The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat.
Gene_expression (distribution) of LE-IR in pituitary associated with dynorphin, enkephalin and hemorrhagic shock
18) Confidence 0.63 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.27 Pain Relevance 0.27
Layer separation of human gut showed that IR-7B2 is mainly (71 +/- 8%) present in the epithelial fraction.
Gene_expression (present) of IR-7B2 in gut
19) Confidence 0.63 Published 1988 Journal Dig. Dis. Sci. Section Abstract Doc Link 3286156 Disease Relevance 0 Pain Relevance 0.09
No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree.
Gene_expression (detected) of INSR associated with migraine
20) Confidence 0.62 Published 2006 Journal Eur J Med Genet Section Title Doc Link 16473310 Disease Relevance 0.80 Pain Relevance 0.64

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